Concordance between rest MIBG and exercise tetrofosmin defects : possible use of rest MIBG imaging as a marker of reversible ischaemia

Perfusion imaging combined with pharmacological stress is the study of choice in patients with ischaemic heart disease who are incapable of exercising. Some medical conditions, however, can preclude the use of pharmacological stress. In these particular situations, availability of a diagnostic test...

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Bibliographic Details
Published in:European Journal of Nuclear Medicine 2001-05, Vol.28 (5), p.614-619
Main Authors: ESTORCH, Montserrat, NARULA, Jagat, FLOTATS, Albert, MARI, Carina, TEMBL, Ana, MARTIN, Joan Carles, DEL VALLE CAMACHO, Maria, CATAFAU, Ana Maria, SERRA-GRIMA, Ricard, CARRIO, Ignasi
Format: Article
Language:English
Subjects:
3-Iodobenzylguanidine
Adult
Aged
Biological and medical sciences
Cardiology. Vascular system
Cardiovascular system
Coronary Circulation
Coronary heart disease
Exercise Test
Heart
Heart - innervation
Humans
Investigative techniques, diagnostic techniques (general aspects)
Male
Medical sciences
Middle Aged
Myocardial Ischemia - diagnostic imaging
Myocardial Ischemia - physiopathology
Organophosphorus Compounds
Organotechnetium Compounds
Radionuclide investigations
Radiopharmaceuticals
Rest
Sympathetic Nervous System - physiopathology
Tomography, Emission-Computed, Single-Photon
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Summary:Perfusion imaging combined with pharmacological stress is the study of choice in patients with ischaemic heart disease who are incapable of exercising. Some medical conditions, however, can preclude the use of pharmacological stress. In these particular situations, availability of a diagnostic test which allows for the assessment of ischaemic territory at rest would be desirable. With the purpose of providing a marker of reversible ischaemia, we evaluated myocardial iodine-123 metaiodobenzylguanidine (MIBG) uptake in regions with fixed and reversible defects defined by exercise/rest perfusion study. Fifty-four male patients with ischaemic heart disease and previous myocardial infarction were studied by means of exercise/rest tetrofosmin and MIBG single-photon emission tomography (SPET). Regional tracer uptake was quantified and expressed as a percentage of maximum peak activity. Areas with denervated but perfused myocardium and areas with ischaemic myocardium were calculated. Regions with10% (reversible regional defect) or
ISSN:0340-6997
1619-7070
1619-7089
DOI:10.1007/s002590100510