Genetic manipulation of spirochetes – light at the end of the tunnel

Spirochetes cause many important diseases in humans and animals, including syphilis, relapsing fever, leptospirosis and Lyme disease. Recent advances in molecular genetics have allowed Koch's molecular postulates to be applied to the study of the virulence factors in these bacteria. Such advanc...

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Bibliographic Details
Published in:Trends in microbiology (Regular ed.) 2001-06, Vol.9 (6), p.245-248
Main Authors: Cabello, Felipe C, Sartakova, Marina L, Dobrikova, Elena Yu
Format: Article
Language:English
Subjects:
Animals
Genetic Techniques
Humans
Spirochaetales
Spirochaetales - classification
Spirochaetales - genetics
Spirochaetales - isolation & purification
Spirochaetales Infections - diagnosis
Spirochaetales Infections - microbiology
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Summary:Spirochetes cause many important diseases in humans and animals, including syphilis, relapsing fever, leptospirosis and Lyme disease. Recent advances in molecular genetics have allowed Koch's molecular postulates to be applied to the study of the virulence factors in these bacteria. Such advances include the use of electroporation, the identification of several antibiotic resistance phenotypes as useful genetic markers, the development of extrachromosomal cloning vectors and the isolation of knockout mutants and their complementation.
ISSN:0966-842X
1878-4380
DOI:10.1016/S0966-842X(01)02046-7