Intrathecal release of sICAM-1 into CSF in neuroborreliosis — increased brain-derived fraction

• Published in: Journal of neuroimmunology 2000-02, Vol.103 (1), p.93-96
• Main Authors: Lewczuk, P, Reiber, H, Korenke, G.C, Bollensen, E, Dorta-Contreras, A.J
• Format: Article
• Language: English
• Subjects: Adhesion molecules; Adolescent; Adult; Aged; Blood–CSF barrier dysfunction; Cerebrospinal fluid; Child; Female; Follow-Up Studies; Humans; Intercellular Adhesion Molecule-1 - blood; Intercellular Adhesion Molecule-1 - cerebrospinal fluid; Lyme Neuroborreliosis - cerebrospinal fluid; Male; Middle Aged; Neuroborreliosis; sICAM-1
• ISSN: 0165-5728; 1872-8421
• DOI: 10.1016/S0165-5728(99)00221-0

In the present study, we report sICAM-1 concentration in the cerebrospinal fluid (CSF) and serum of patients with neuroborreliosis (NB, n=11), compared to the data from a control group of patients with corresponding blood/CSF barrier dysfunction but without inflammation in the central nervous system (disc prolaps, DP, n=11). In NB, the sICAM-1 concentration in CSF was increased up to six-fold (ranges: 6.6–42.8 ng/ml and 2.2–9.8 ng/ml for NB and DP respectively) with no change in serum sICAM-1. The corresponding sICAM-1 CSF/serum concentration quotients ( Q ICAM) were in the ranges: 22.5–171.3×10 −3, and 8.8–27.8×10 −3 for NB and DP respectively. This finding can be explained by increase of the brain-derived fraction of sICAM-1 in NB. In one case we observed increased Q ICAM on 6th day after admission to the hospital (171.3×10 −3 at the time of the first lumbar puncture slightly increasing to 243.6×10 −3 five days later), followed by normalization, in two remaining repunctured patients we observed decreasing Q ICAM with normalizing Q Alb.