Design, optimization and evaluation of domperidone coevaporates

Coevaporates of domperidone were prepared using different polymers by solvent evaporation technique. Ethyl cellulose and hydroxypropyl methylcellulose phthalate were used in preparation of coevaporates. The coevaporates were characterized by X-ray diffraction studies, IR spectrophotometry and differ...

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Bibliographic Details
Published in:Journal of controlled release 2000-01, Vol.63 (1-2), p.31-39
Main Authors: Nagarsenker, M.S, Garad, S.D, Ramprakash, G
Format: Article
Language:English
Subjects:
Adult
Bioavailability
Biological and medical sciences
Biological Availability
Catecholaminergic system
Coevaporates
Delayed-Action Preparations
Dissolution
Domperidone
Domperidone - administration & dosage
Domperidone - chemical synthesis
Domperidone - pharmacokinetics
Dopamine Antagonists - administration & dosage
Dopamine Antagonists - chemical synthesis
Dopamine Antagonists - pharmacokinetics
Drug Carriers
General pharmacology
Humans
Hydrogen-Ion Concentration
Male
Medical sciences
Neuropharmacology
Neurotransmitters. Neurotransmission. Receptors
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Physical characterization
Solubility
Tablets
Volatilization
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Summary:Coevaporates of domperidone were prepared using different polymers by solvent evaporation technique. Ethyl cellulose and hydroxypropyl methylcellulose phthalate were used in preparation of coevaporates. The coevaporates were characterized by X-ray diffraction studies, IR spectrophotometry and differential scanning calorimetry. The dissolution behavior of coevaporates was studied using buffer solution of pH 1.2 for the first 2 h and that of pH 6.8 thereafter up to 12 h. A two-factor, three-level design was used to quantitate the effect of polymers on dissolution profile of domperidone. The drug release rate was found to be dependent on the concentration of polymers in the coevaporates. Dissolution of drug in a pH 6.8 buffer improved with increasing concentration of hydroxypropyl methylcellulose phthalate in coevaporates. Bioavailability studies in human volunteers confirmed that domperidone coevaporates sustained drug release.
ISSN:0168-3659
1873-4995
DOI:10.1016/S0168-3659(99)00177-7