A Nozaki−Hiyama−Kishi Ni(II)/Cr(II) Coupling Approach to the Phomactins

Through a unified synthetic strategy, appropriately functionalized bicyclic starting materials can be elaborated via Ni(II)/Cr(II) macrocylization to [9.3.1] bicycles. Elaboration of these core structures allows access to phomactin C/D analogues and establishes the first synthetic approach to phomac...

Full description

Saved in:
Bibliographic Details
Published in:Organic letters 2001-05, Vol.3 (10), p.1491-1494
Main Authors: Mi, Baoyu, Maleczka, Robert E
Format: Article
Language:English
Subjects:
Animals
Chromium - chemistry
Epoxy Compounds
Fungi - chemistry
Guanidines - chemical synthesis
Heterocyclic Compounds, 4 or More Rings - chemical synthesis
Humans
Marine Biology
Nickel - chemistry
Platelet Activating Factor - antagonists & inhibitors
Platelet Aggregation Inhibitors - chemical synthesis
Spiro Compounds - chemical synthesis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Through a unified synthetic strategy, appropriately functionalized bicyclic starting materials can be elaborated via Ni(II)/Cr(II) macrocylization to [9.3.1] bicycles. Elaboration of these core structures allows access to phomactin C/D analogues and establishes the first synthetic approach to phomactin A affording an intact octahydrochromene/macrocyclic ring system.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol015807q