Inhibitor of neurite outgrowth in humans

Axons are generally believed to be incapable of regeneration in the adult central nervous system. Inhibition results from physical barriers imposed by glial scars, a lack of neurotrophic factors, and growth-inhibitory molecules associated with myelin, the insulating axon sheath. These molecules incl...

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Bibliographic Details
Published in:Nature (London) 2000-01, Vol.403 (6768), p.383-384
Main Authors: PRINJHA, R, MOORE, S. E, VINSON, M, BLAKE, S, MORROW, R, CHRISTIE, G, MICHALOVICH, D, SIMMONS, D. L, WALSH, F. S
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Cattle
Development. Senescence. Regeneration. Transplantation
Fundamental and applied biological sciences. Psychology
Growth Inhibitors - genetics
Growth Inhibitors - physiology
Humans
In Vitro Techniques
Membrane Proteins - genetics
Membrane Proteins - physiology
Molecular Sequence Data
Myelin Proteins - genetics
Myelin Proteins - physiology
Nerve Regeneration
Neurites - physiology
Nogo protein
Nogo Proteins
Protein Isoforms
Vertebrates: nervous system and sense organs
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Summary:Axons are generally believed to be incapable of regeneration in the adult central nervous system. Inhibition results from physical barriers imposed by glial scars, a lack of neurotrophic factors, and growth-inhibitory molecules associated with myelin, the insulating axon sheath. These molecules include proteoglycans, myelin-associated glycoprotein and, in bovine brain, two proteins called Nogo. We have used this bovine sequence to identify the human Nogo gene and have isolated complementary DNA clones encoding three different Nogo isoforms that are potent inhibitors of neurine outgrowth and which may help block the regeneration of the central nervous system in adults.
ISSN:0028-0836
1476-4687
DOI:10.1038/35000287