The beta-1,3-galactosyltransferase-4 (B3GALT4) gene is located in the centromeric segment of the human MHC class II region

The beta -1,3-galactosyltransferase-4 gene (B3GALT4), encoding a UDP-galactose: beta -N-acetyl-galactosamine beta -1,3-galactosyltransferase activity (Amado et al. 1998), is one of the most recent additions to the human beta -3-galactosyltransferase gene family. Recently identified through expressed...

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Bibliographic Details
Published in:Immunogenetics (New York) 2000-01, Vol.51 (1), p.75-78
Main Authors: Shiina, T, Kikkawa, E, Iwasaki, H, Kaneko, M, Narimatsu, H, Sasaki, K, Bahram, S, Inoko, H
Format: Article
Language:English
Subjects:
b-1,3-galactosyltransferase
b-1,3-galactosyltransferase 4
B3GALT4 gene
Base Composition
Centromere - genetics
chromosome 6
Contig Mapping
CpG Islands - genetics
Exons - genetics
Expressed sequence tags
Galactosyltransferases - genetics
Genes, MHC Class II - genetics
Genetic Linkage - genetics
histocompatibility locus HLA
HLA-DP Antigens - genetics
Humans
Introns - genetics
Molecular Sequence Data
Physical Chromosome Mapping
Polymerase Chain Reaction
Ribosomal Proteins - genetics
RNA, Messenger - analysis
RNA, Messenger - genetics
Software
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Summary:The beta -1,3-galactosyltransferase-4 gene (B3GALT4), encoding a UDP-galactose: beta -N-acetyl-galactosamine beta -1,3-galactosyltransferase activity (Amado et al. 1998), is one of the most recent additions to the human beta -3-galactosyltransferase gene family. Recently identified through expressed sequence tag (EST) analysis, the gene has been mapped to Chromosome 6p21.3 (Amado et al. 1998), a region noted for the presence of the human major histocompatibility complex (MHC) (also known as the HLA gene cluster). A cDNA clone, G5, encoding human B3GALT4 was isolated and analyzed [1655-base pair (bp) clone G5; accession number AB026730; Isshiki 1999]. The G5 clone encodes human B3GALT4 which is a homologue of rat GM1/GD1 synthase (Miyazaki et al. 1997). The GM1/GD1 synthase transfers a galactose to the N-acetylgalactosamine residue of GM2/GD2 with beta 1-3 linkage.
ISSN:0093-7711
1432-1211
DOI:10.1007/s002510050012