Cellular and molecular basis of preferential metastasis of breast cancer to bone

Bone is one of the most preferential target sites for cancer metastasis. Breast cancer has a predilection for spreading to bone, and bone metastasis is one of the major causes of increased morbidity and eventual mortality in breast cancer patients. None of the currently available therapies is effect...

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Bibliographic Details
Published in:Journal of orthopaedic science (Print) 2000-01, Vol.5 (1), p.75-81
Main Author: Yoneda, Toshiyuki
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
bisphosphonate
bone metastasis
Bone Neoplasms - metabolism
Bone Neoplasms - secondary
Bone Resorption - physiopathology
Breast cancer
Breast Neoplasms - metabolism
Breast Neoplasms - pathology
Cadherins - metabolism
Diphosphonates - metabolism
Disease Models, Animal
Diseases of the osteoarticular system
Gynecology. Andrology. Obstetrics
Humans
Integrin alpha4beta1
Integrins - metabolism
Laminin - metabolism
Mammary gland diseases
Matrix Metalloproteinases - metabolism
Medical research
Medical sciences
Neoplasm Metastasis - physiopathology
Neoplasm Proteins - metabolism
osteoclastic bone resorption
Parathyroid Hormone-Related Protein
Proteins - metabolism
Receptors, Lymphocyte Homing - metabolism
Tumors
Tumors of striated muscle and skeleton
Vascular Cell Adhesion Molecule-1 - metabolism
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Summary:Bone is one of the most preferential target sites for cancer metastasis. Breast cancer has a predilection for spreading to bone, and bone metastasis is one of the major causes of increased morbidity and eventual mortality in breast cancer patients. None of the currently available therapies is effective for curing bone metastases in these patients. Elucidation of the cellular and molecular mechanism by which breast cancer selectively spreads to bone is essential for the development of mechanism-based effective and specific therapeutic interventions for this deleterious complication in breast cancer. Here, two questions are addressed to study the mechanism of breast cancer metastasis to bone: (1) What makes bone a preferential target site of metastasis? (2) What makes breast cancer able to colonize bone? (3) An animal model in which intracardiac inoculation of breast cancer cells selectively causes osteolytic bone metastases was developed. Experimental results obtained using this unique in-vivo model of bone metastasis are described and discussed.
ISSN:0949-2658
1436-2023
DOI:10.1007/s007760050012