Fine‐needle aspiration characteristics of hibernoma

BACKGROUND Hibernoma is a rare, benign lipomatous tumor with features of brown fat. The preoperative diagnosis of hibernoma is difficult at times because its clinical, radiographic, and fine‐needle aspiration (FNA) characteristics overlap with those of liposarcoma. METHODS The preoperative FNA findi...

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Bibliographic Details
Published in:Cancer 2001-06, Vol.93 (3), p.206-210
Main Authors: Lemos, Maria M., Kindblom, Lars‐Gunnar, Meis‐Kindblom, Jeanne M., Remotti, Fabrizio, Ryd, Walter, Gunterberg, Björn, Willén, Helena
Format: Article
Language:English
Subjects:
Adipose Tissue, Brown
Adult
Biological and medical sciences
Biopsy, Needle - methods
Cytodiagnosis
cytology
Diagnosis, Differential
Female
fine‐needle aspiration
hibernoma
Humans
Investigative techniques, diagnostic techniques (general aspects)
lipoma
Lipoma - pathology
liposarcoma
Male
Medical sciences
Middle Aged
Miscellaneous. Technology
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Soft Tissue Neoplasms - pathology
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Summary:BACKGROUND Hibernoma is a rare, benign lipomatous tumor with features of brown fat. The preoperative diagnosis of hibernoma is difficult at times because its clinical, radiographic, and fine‐needle aspiration (FNA) characteristics overlap with those of liposarcoma. METHODS The preoperative FNA findings of eight surgically excised hibernomas from seven patients (three men and four women, ages 24–60 years) were reviewed. The cytologic features were compared with the histologic features of the corresponding surgical specimens as well as lipomatous tumors and other lesions that may cause confusion in the differential diagnosis. RESULTS The FNA cytologic features of the hibernomas were found to correspond well with their histologic appearance. The FNA findings included small, round, brown fat‐like cells with uniform, small cytoplasmic vacuoles and regular, small, round nuclei; delicate branching capillaries; and variable numbers of mature fat cells. CONCLUSIONS The FNA cytologic features of hibernoma are characteristic and useful in the preoperative investigation of lipomatous tumors, particularly with regard to excluding a diagnosis of liposarcoma. Cancer (Cancer Cytopathol) 2001;93:206–210. © 2001 American Cancer Society. The appearance of hibernoma on fine‐needle aspiration is characteristic, allowing for its reliable distinction from liposarcoma preoperatively.
ISSN:0008-543X
1097-0142
DOI:10.1002/cncr.9030