α-Substituted N-(Sulfonamido)alkyl-β-aminotetralins:  Potent and Selective Neuropeptide Y Y5 Receptor Antagonists

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Bibliographic Details
Published in:Journal of medicinal chemistry 2000-02, Vol.43 (3), p.346-350
Main Authors: Youngman, Mark A, McNally, James J, Lovenberg, Timothy W, Reitz, Allen B, Willard, Nicole M, Nepomuceno, Diane H, Wilson, Sandy J, Crooke, Jeffrey J, Rosenthal, Daniel, Vaidya, Anil H, Dax, Scott L
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cell Line
Humans
Medical sciences
Neuropharmacology
Neurotransmitters. Neurotransmission. Receptors
Peptidergic system (neuropeptide, opioid peptide, opiates...). Adenosinergic and purinergic systems
Pharmacology. Drug treatments
Radioligand Assay
Receptors, Neuropeptide Y - antagonists & inhibitors
Structure-Activity Relationship
Sulfonamides - chemical synthesis
Sulfonamides - chemistry
Sulfonamides - pharmacology
Tetrahydronaphthalenes - chemical synthesis
Tetrahydronaphthalenes - chemistry
Tetrahydronaphthalenes - metabolism
Transfection
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ISSN:0022-2623
1520-4804
DOI:10.1021/jm990468g