Signaling by extracellular nucleotides in anterior pituitary cells

Pituitary cells secrete ATP, which acts as an autocrine and/or paracrine extracellular messenger on two families of purinergic receptors: G-protein-coupled P2Y receptors (P2YRs) and ion-conducting P2X receptors (P2XRs). Lactotrophs and GH 3-immortalized cells express the P2Y 2R subtype. Several P2XR...

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Bibliographic Details
Published in:Trends in Endocrinology & Metabolism 2001-07, Vol.12 (5), p.218-225
Main Authors: Stojilkovic, Stanko S, Koshimizu, Taka-aki
Format: Article
Language:English
Subjects:
Adenosine Triphosphate - metabolism
Adenosine Triphosphate - secretion
Animals
anterior pituitary
ATP
Autocrine Communication
Biological and medical sciences
Calcium Signaling
extracellular nucleotides
Fundamental and applied biological sciences. Psychology
Gonadotrophs
Heterotrimeric GTP-Binding Proteins - metabolism
Hormones and neuropeptides. Regulation
Humans
Hypothalamus. Hypophysis. Epiphysis. Urophysis
Lactotophs
Paracrine Communication
Pituitary Gland, Anterior - cytology
Pituitary Gland, Anterior - metabolism
Pituitary Gland, Anterior - secretion
Receptors, Purinergic P1 - metabolism
Receptors, Purinergic P2 - chemistry
Receptors, Purinergic P2 - genetics
Receptors, Purinergic P2 - metabolism
RNA, Messenger - genetics
RNA, Messenger - metabolism
signaling
somatotrophs
Vertebrates: endocrinology
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Summary:Pituitary cells secrete ATP, which acts as an autocrine and/or paracrine extracellular messenger on two families of purinergic receptors: G-protein-coupled P2Y receptors (P2YRs) and ion-conducting P2X receptors (P2XRs). Lactotrophs and GH 3-immortalized cells express the P2Y 2R subtype. Several P2XR subtypes are expressed in pituitary cells. Gonadotrophs and somatotrophs express P2X 2aR and P2X 2bR, which occur as heteromeric channels. Lactotrophs and GH 3 cells express one or more ion-conducting subtypes from among P2X 3R, P2X 4R and P2X 7R in homomeric form. Thyrotrophs and corticotrophs also express P2XRs, but their identification requires further study. Pituitary cells express purinergic P1 receptors, which are activated by adenosine. The A 1R subtype of these receptors is expressed in melanotrophs and GH 3 cells. In this review, we briefly discuss the expression and coupling of A 1R and P2Y 2R, and focus on the expression and Ca 2+ signaling of P2XRs.
ISSN:1043-2760
1879-3061
DOI:10.1016/S1043-2760(01)00387-3