Peptidergic correction of the effect of acute hypobaric hypoxia in pregnant rats on progeny

Acute hypobaric hypoxia of pregnant rats led to a significant delay in body weight gain, growth and time of eye opening in newborn rat pups which was paralleled by behavioral changes. Preventive intranasal instillations of peptide mixture (semax and beta-casomorphine-7) to pregnant females prevented...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2001-02, Vol.131 (2), p.109-112
Main Authors: Maslova, M V, Zemlyanskii, K S, Shkol'nikova, M V, Maklakova, A S, Krushinskaya, Y V, Sokolova, N A, Ashmarin, I P
Format: Article
Language:English
Subjects:
Adrenocorticotropic Hormone - analogs & derivatives
Adrenocorticotropic Hormone - pharmacology
Analgesics, Opioid - pharmacology
Animals
Animals, Newborn
Behavior, Animal - physiology
Body Weight
Endorphins - pharmacology
Female
Fetal Hypoxia - drug therapy
Fetal Hypoxia - physiopathology
Hypoxia - physiopathology
Male
Maze Learning - drug effects
Neuroprotective Agents - pharmacology
Peptide Fragments - pharmacology
Pregnancy
Rats
Receptors, Opioid, mu - agonists
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Summary:Acute hypobaric hypoxia of pregnant rats led to a significant delay in body weight gain, growth and time of eye opening in newborn rat pups which was paralleled by behavioral changes. Preventive intranasal instillations of peptide mixture (semax and beta-casomorphine-7) to pregnant females prevented the effect of hypoxia on the progeny.
ISSN:0007-4888
1573-8221
DOI:10.1023/A:1017515206152