Early experience of intra‐ureteric capsaicin infusion in loin pain haematuria syndrome

• Published in: BJU international 2000-02, Vol.85 (3), p.233-237
• Main Authors: Armstrong, T., Mclean, A.D., Hayes, M., Morgans, B.T., Tulloch, D.N.
• Format: Article
• Language: English
• Subjects: Administration, Topical; Adult; Algorithms; Biological and medical sciences; capsaicin; Capsaicin - administration & dosage; complications; Female; Hematuria - drug therapy; Humans; instillation; Loin pain haematuria syndrome; Male; Medical sciences; Middle Aged; Pain - drug therapy; Patient Selection; Pharmacology. Drug treatments; Syndrome; Treatment Outcome; Urinary system
• ISSN: 1464-4096; 1464-410X
• DOI: 10.1046/j.1464-410x.2000.00469.x

Objectives To evaluate early results of the intra‐ureteric instillation of capsaicin for the treatment of loin pain haematuria syndrome (LPHS). Patients and methods Ten patients with LPHS were treated using intra‐ureteric capsaicin instillation. A solution of capsaicin was infused into the affected ureter through an embolectomy catheter, under anaesthesia. The success of the treatment was assessed using patient questionnaires and the quantitative reduction in the patients’ analgesic requirements measured. Results During a mean follow‐up of 6 months, six of the 10 patients had short‐ to medium‐term symptomatic relief after one or more treatments; four had no relief from their symptoms. One patient had a mucosal ulceration in the bladder after extravasation of the capsaicin solution. Two patients subsequently underwent simple nephrectomy for symptomatic nonfunctioning kidneys. Conclusion These results are consistent with other preliminary reports of the efficacy of capsaicin treatment in LPHS and such treatment therefore has a definite therapeutic role in this difficult condition. We are uncertain if the treatment contributed to the deterioration of the excised kidneys. This early experience suggests a need for careful consideration when contemplating this treatment, with attention directed to both the initial diagnosis and possibly the technique of capsaicin/instillation. We include a protocol to follow when preparing patients for capsaicin treatment.