Breslow thickness and Clark level in melanoma : Support for including level in pathology reports and in American Joint Committee on Cancer staging

• Published in: Cancer 2000-02, Vol.88 (3), p.589-595
• Main Authors: MARGHOOB, A. A, KOENIG, K, BITTENCOURT, F. V, KOPF, A. W, BART, R. S
• Format: Article
• Language: English
• Subjects: Adult; Age Factors; Aged; Biological and medical sciences; Cause of Death; Databases as Topic; Dermatology; Female; Follow-Up Studies; Humans; Male; Medical sciences; Melanoma - pathology; Middle Aged; Neoplasm Invasiveness; Neoplasm Staging - methods; Neoplasm Staging - statistics & numerical data; Prognosis; Proportional Hazards Models; Skin Neoplasms - pathology; Skin Ulcer - pathology; Survival Analysis; Tumors of the skin and soft tissue. Premalignant lesions
• ISSN: 0008-543X; 1097-0142
• DOI: 10.1002/(SICI)1097-0142(20000201)88:3<589::AID-CNCR15>3.0.CO;2-I

Thickness is known to be an important survival prognosticator for cutaneous melanoma, but controversy exists as to whether Clark level of invasion retains prognostic significance once thickness has been accounted for. A recent proposal to eliminate Clark level from the staging system for melanoma of the American Joint Committee on Cancer (AJCC) prompted the authors to investigate whether level adds useful prognostic information to Breslow thickness. They used the data base of the New York University Melanoma Cooperative Group (NYU-MCG) Registry. The analysis was based on 919 patients with AJCC Stage I or II melanomas diagnosed between 1972 and 1982 and followed for an average of 10.9 years. Melanoma thicknesses were divided into 4 categories (< or = 0.75, 0.76-1.50, 1.51-4.00, and >4.00 mm). Patients were cross-classified according to tumor thickness and Clark level (II-V). For each combination of thickness and level, the Kaplan-Meier survival curve and 10-year survival proportion were computed, using death from melanoma as the outcome. The impact of Clark level on survival was evaluated for each of the thickness categories. The Cox proportional hazards model was used to assess the simultaneous effect of thickness and level on survival while controlling for other important prognostic factors, i.e., age, tumor location, and presence or absence of ulceration. Level of invasion was a significant predictor of death from melanoma in each of the four thickness categories. Likewise, in the Cox analyses, level was a significant prognostic variable, even after thickness was included in the model and regardless of whether thickness was treated as a categoric or a continuous variable. These results confirm that both tumor thickness and level of invasion are important independent prognostic factors in AJCC Stage I and II melanomas. The authors recommend that Clark levels be kept as criteria in the AJCC staging system and be included in pathology reports. [See editorial on pages 491-6, this issue.]