Transmucosal transport of tobramycin incorporated in solid lipid nanoparticles (sln) after duodenal administration to rats. Part II—Tissue distribution

Tobramycin-loaded solid lipid nanoparticles (SLN) were prepared and administered by duodenal and intravenous (i.v.) routes to rats and the tissue distributions were determined successively at fixed times (30 min, 4 h and 24 h) and compared to those of the tobramycin solution after i.v. administratio...

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Bibliographic Details
Published in:Pharmacological research 2001-05, Vol.43 (5), p.497-502
Main Authors: Bargoni, Alessandro, Cavalli, Roberta, Zara, Gian Paolo, Fundarò, Anna, Caputo, Otto, Gasco, Maria Rosa
Format: Article
Language:English
Subjects:
Animals
Anti-Bacterial Agents - administration & dosage
Anti-Bacterial Agents - pharmacokinetics
Drug Carriers
duodenal administration, intravenous administration, tobramycin-loaded solid lipid nanoparticles, tobramycin tissue distribution, blood–brain barrier
Duodenum - physiology
Injections
Injections, Intravenous
Intestinal Absorption
Intestinal Mucosa - drug effects
Intestinal Mucosa - metabolism
Liposomes
Male
Pharmaceutical Solutions
Rats
Rats, Wistar
Tissue Distribution
Tobramycin - administration & dosage
Tobramycin - pharmacokinetics
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Summary:Tobramycin-loaded solid lipid nanoparticles (SLN) were prepared and administered by duodenal and intravenous (i.v.) routes to rats and the tissue distributions were determined successively at fixed times (30 min, 4 h and 24 h) and compared to those of the tobramycin solution after i.v. administration. The tissue distribution between tobramycin-loaded SLN administered duodenally and i.v. was different. A marked difference between tobramycin-loaded SLN administered duodenally and tobramycin solution administered i.v. was also evidenced. In particular, the amounts of tobramycin in the kidneys after tobramycin-loaded SLN administration either duodenally or i.v. were lower than after administration of i.v. solution. Tobramycin-loaded SLN were able to pass across the blood–brain barrier in rats to a greater extent after i.v. injection than after duodenal administration.
ISSN:1043-6618
1096-1186
DOI:10.1006/phrs.2001.0813