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Evaluation of chemotherapy response using technetium‐99M‐sestamibi scintigraphy in untreated adult malignant lymphomas and comparison with other prognosis factors: A preliminary report
The purpose of this study was to predict chemotherapy response using technetium‐99m methoxyisobutylisonitrile (Tc‐MIBI) scintigraphy in untreated adult malignant lymphomas (ML) and compare the response with other prognosis factors. Before chemotherapy, 25 adult patients with ML were enrolled in this...
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| Published in: | International journal of cancer 2001-07, Vol.95 (4), p.228-231 |
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| container_end_page | 231 |
| container_issue | 4 |
| container_start_page | 228 |
| container_title | International journal of cancer |
| container_volume | 95 |
| creator | Kao, Chia‐Hung Tsai, Shih‐Chuan Wang, Jhi‐Joung Ho, Yung‐Jen Ho, Shung‐Tai Changlai, Sheng‐Ping |
| description | The purpose of this study was to predict chemotherapy response using technetium‐99m methoxyisobutylisonitrile (Tc‐MIBI) scintigraphy in untreated adult malignant lymphomas (ML) and compare the response with other prognosis factors. Before chemotherapy, 25 adult patients with ML were enrolled in this study. Tc‐MIBI scintigraphy was performed 10 min after intravenous injection of Tc‐MIBI to calculate tumor‐to‐background (T/B) uptake ratio and interpret the results visually. Chemotherapy response was evaluated in the first 1 to 2 years after completion of treatment by clinical and radiological methods. The mean T/B uptake ratio of the 15 patients with good response (3.3 ± 0.6) was significantly higher than that of the 10 patients with poor response (1.2 ± 0.1). All of the 15 patients with good response had positive Tc‐MIBI scintigraphic results. All of the 10 patients with poor response had negative Tc‐MIBI scintigraphic results. However, there were no significant differences in the incidences of good and poor responses for other prognosis factors. In our preliminary study, when compared with other prognosis factors, Tc‐MIBI scintigraphy was the best tool to predict chemotherapy response in adult patients with ML. © 2001 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/1097-0215(20010720)95:4<228::AID-IJC1039>3.0.CO;2-D |
| format | article |
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Before chemotherapy, 25 adult patients with ML were enrolled in this study. Tc‐MIBI scintigraphy was performed 10 min after intravenous injection of Tc‐MIBI to calculate tumor‐to‐background (T/B) uptake ratio and interpret the results visually. Chemotherapy response was evaluated in the first 1 to 2 years after completion of treatment by clinical and radiological methods. The mean T/B uptake ratio of the 15 patients with good response (3.3 ± 0.6) was significantly higher than that of the 10 patients with poor response (1.2 ± 0.1). All of the 15 patients with good response had positive Tc‐MIBI scintigraphic results. All of the 10 patients with poor response had negative Tc‐MIBI scintigraphic results. However, there were no significant differences in the incidences of good and poor responses for other prognosis factors. In our preliminary study, when compared with other prognosis factors, Tc‐MIBI scintigraphy was the best tool to predict chemotherapy response in adult patients with ML. © 2001 Wiley‐Liss, Inc.</description><identifier>ISSN: 0020-7136</identifier><identifier>EISSN: 1097-0215</identifier><identifier>DOI: 10.1002/1097-0215(20010720)95:4<228::AID-IJC1039>3.0.CO;2-D</identifier><identifier>PMID: 11400115</identifier><identifier>CODEN: IJCNAW</identifier><language>eng</language><publisher>New York: John Wiley & Sons, Inc</publisher><subject>Adult ; Aged ; Antineoplastic agents ; Biological and medical sciences ; Chemotherapy ; chemotherapy response ; Drug Resistance, Neoplasm ; Female ; Humans ; Lymphoma - diagnostic imaging ; Lymphoma - drug therapy ; Lymphoma - pathology ; Male ; malignant lymphoma ; Medical sciences ; Middle Aged ; Pharmacology. Drug treatments ; Predictive Value of Tests ; Prognosis ; Radionuclide Imaging ; Radiopharmaceuticals ; Statistics, Nonparametric ; Technetium Tc 99m Sestamibi ; technetium‐99m methoxyisobutylisonitrile</subject><ispartof>International journal of cancer, 2001-07, Vol.95 (4), p.228-231</ispartof><rights>Copyright © 2001 Wiley‐Liss, Inc.</rights><rights>2002 INIST-CNRS</rights><rights>Copyright 2001 Wiley-Liss, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3939-3cbb97155e438de62ffcbde03effed0c7fb7ecc5dca77127c8e2a109e039ac603</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14077299$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11400115$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kao, Chia‐Hung</creatorcontrib><creatorcontrib>Tsai, Shih‐Chuan</creatorcontrib><creatorcontrib>Wang, Jhi‐Joung</creatorcontrib><creatorcontrib>Ho, Yung‐Jen</creatorcontrib><creatorcontrib>Ho, Shung‐Tai</creatorcontrib><creatorcontrib>Changlai, Sheng‐Ping</creatorcontrib><title>Evaluation of chemotherapy response using technetium‐99M‐sestamibi scintigraphy in untreated adult malignant lymphomas and comparison with other prognosis factors: A preliminary report</title><title>International journal of cancer</title><addtitle>Int J Cancer</addtitle><description>The purpose of this study was to predict chemotherapy response using technetium‐99m methoxyisobutylisonitrile (Tc‐MIBI) scintigraphy in untreated adult malignant lymphomas (ML) and compare the response with other prognosis factors. Before chemotherapy, 25 adult patients with ML were enrolled in this study. Tc‐MIBI scintigraphy was performed 10 min after intravenous injection of Tc‐MIBI to calculate tumor‐to‐background (T/B) uptake ratio and interpret the results visually. Chemotherapy response was evaluated in the first 1 to 2 years after completion of treatment by clinical and radiological methods. The mean T/B uptake ratio of the 15 patients with good response (3.3 ± 0.6) was significantly higher than that of the 10 patients with poor response (1.2 ± 0.1). All of the 15 patients with good response had positive Tc‐MIBI scintigraphic results. All of the 10 patients with poor response had negative Tc‐MIBI scintigraphic results. However, there were no significant differences in the incidences of good and poor responses for other prognosis factors. In our preliminary study, when compared with other prognosis factors, Tc‐MIBI scintigraphy was the best tool to predict chemotherapy response in adult patients with ML. © 2001 Wiley‐Liss, Inc.</description><subject>Adult</subject><subject>Aged</subject><subject>Antineoplastic agents</subject><subject>Biological and medical sciences</subject><subject>Chemotherapy</subject><subject>chemotherapy response</subject><subject>Drug Resistance, Neoplasm</subject><subject>Female</subject><subject>Humans</subject><subject>Lymphoma - diagnostic imaging</subject><subject>Lymphoma - drug therapy</subject><subject>Lymphoma - pathology</subject><subject>Male</subject><subject>malignant lymphoma</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pharmacology. Drug treatments</subject><subject>Predictive Value of Tests</subject><subject>Prognosis</subject><subject>Radionuclide Imaging</subject><subject>Radiopharmaceuticals</subject><subject>Statistics, Nonparametric</subject><subject>Technetium Tc 99m Sestamibi</subject><subject>technetium‐99m methoxyisobutylisonitrile</subject><issn>0020-7136</issn><issn>1097-0215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><recordid>eNqVkcGO0zAQhiMEYpeFV0C-gOCQYjtJXXcRUtUuULSoB0AcLceZNEaxnbUdVr3xCDwQT8OT4G677IULF1seffPP7_mz7JzgCcGYviKYsxxTUr2gGBPMKH7Jq3n5mtLZfL5Yr_L1hyXBBX9TTPBkuTmn-epedvq36352mlRwzkgxPckehfAtqZAKlw-zE0LKm8dp9uviu-xHGbWzyLVIdWBc7MDLYYc8hMHZAGgM2m5RBNVZiHo0v3_85PxjOgOEKI2uNQpK26i3qa_bIW3RaKMHGaFBshn7iIzs9dZKG1G_M0PnjAxI2gYpZwbpdUjjr3Xs0M1wNHi3tS7ogFqpovNhjhapCL022kq_tzY4Hx9nD1rZB3hyvM-yL28vPi_f55ebd-vl4jJXBS94Xqi65oxUFZTFrIEpbVtVN4ALaFtosGJtzUCpqlGSMUKZmgGVaY-J4FJNcXGWPT_oJl9XY_qzMDoo6HtpwY1BMMzT1qc0gZ8OoPIuBA-tGLw2ybAgWOxDFft4xD4ecRuq4JUoRQpViBSqOIYqCoHFciOoWCXVp8fxY22gudM8ppiAZ0dABiX71kurdLjjSswY5TxxXw_cte5h91_e_m3ttlT8AaBn0P0</recordid><startdate>20010720</startdate><enddate>20010720</enddate><creator>Kao, Chia‐Hung</creator><creator>Tsai, Shih‐Chuan</creator><creator>Wang, Jhi‐Joung</creator><creator>Ho, Yung‐Jen</creator><creator>Ho, Shung‐Tai</creator><creator>Changlai, Sheng‐Ping</creator><general>John Wiley & Sons, Inc</general><general>Wiley-Liss</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20010720</creationdate><title>Evaluation of chemotherapy response using technetium‐99M‐sestamibi scintigraphy in untreated adult malignant lymphomas and comparison with other prognosis factors: A preliminary report</title><author>Kao, Chia‐Hung ; Tsai, Shih‐Chuan ; Wang, Jhi‐Joung ; Ho, Yung‐Jen ; Ho, Shung‐Tai ; Changlai, Sheng‐Ping</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3939-3cbb97155e438de62ffcbde03effed0c7fb7ecc5dca77127c8e2a109e039ac603</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Antineoplastic agents</topic><topic>Biological and medical sciences</topic><topic>Chemotherapy</topic><topic>chemotherapy response</topic><topic>Drug Resistance, Neoplasm</topic><topic>Female</topic><topic>Humans</topic><topic>Lymphoma - diagnostic imaging</topic><topic>Lymphoma - drug therapy</topic><topic>Lymphoma - pathology</topic><topic>Male</topic><topic>malignant lymphoma</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pharmacology. Drug treatments</topic><topic>Predictive Value of Tests</topic><topic>Prognosis</topic><topic>Radionuclide Imaging</topic><topic>Radiopharmaceuticals</topic><topic>Statistics, Nonparametric</topic><topic>Technetium Tc 99m Sestamibi</topic><topic>technetium‐99m methoxyisobutylisonitrile</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kao, Chia‐Hung</creatorcontrib><creatorcontrib>Tsai, Shih‐Chuan</creatorcontrib><creatorcontrib>Wang, Jhi‐Joung</creatorcontrib><creatorcontrib>Ho, Yung‐Jen</creatorcontrib><creatorcontrib>Ho, Shung‐Tai</creatorcontrib><creatorcontrib>Changlai, Sheng‐Ping</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kao, Chia‐Hung</au><au>Tsai, Shih‐Chuan</au><au>Wang, Jhi‐Joung</au><au>Ho, Yung‐Jen</au><au>Ho, Shung‐Tai</au><au>Changlai, Sheng‐Ping</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of chemotherapy response using technetium‐99M‐sestamibi scintigraphy in untreated adult malignant lymphomas and comparison with other prognosis factors: A preliminary report</atitle><jtitle>International journal of cancer</jtitle><addtitle>Int J Cancer</addtitle><date>2001-07-20</date><risdate>2001</risdate><volume>95</volume><issue>4</issue><spage>228</spage><epage>231</epage><pages>228-231</pages><issn>0020-7136</issn><eissn>1097-0215</eissn><coden>IJCNAW</coden><abstract>The purpose of this study was to predict chemotherapy response using technetium‐99m methoxyisobutylisonitrile (Tc‐MIBI) scintigraphy in untreated adult malignant lymphomas (ML) and compare the response with other prognosis factors. Before chemotherapy, 25 adult patients with ML were enrolled in this study. Tc‐MIBI scintigraphy was performed 10 min after intravenous injection of Tc‐MIBI to calculate tumor‐to‐background (T/B) uptake ratio and interpret the results visually. Chemotherapy response was evaluated in the first 1 to 2 years after completion of treatment by clinical and radiological methods. The mean T/B uptake ratio of the 15 patients with good response (3.3 ± 0.6) was significantly higher than that of the 10 patients with poor response (1.2 ± 0.1). All of the 15 patients with good response had positive Tc‐MIBI scintigraphic results. All of the 10 patients with poor response had negative Tc‐MIBI scintigraphic results. However, there were no significant differences in the incidences of good and poor responses for other prognosis factors. In our preliminary study, when compared with other prognosis factors, Tc‐MIBI scintigraphy was the best tool to predict chemotherapy response in adult patients with ML. © 2001 Wiley‐Liss, Inc.</abstract><cop>New York</cop><pub>John Wiley & Sons, Inc</pub><pmid>11400115</pmid><doi>10.1002/1097-0215(20010720)95:4<228::AID-IJC1039>3.0.CO;2-D</doi><tpages>4</tpages></addata></record> |
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| ispartof | International journal of cancer, 2001-07, Vol.95 (4), p.228-231 |
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| subjects | Adult Aged Antineoplastic agents Biological and medical sciences Chemotherapy chemotherapy response Drug Resistance, Neoplasm Female Humans Lymphoma - diagnostic imaging Lymphoma - drug therapy Lymphoma - pathology Male malignant lymphoma Medical sciences Middle Aged Pharmacology. Drug treatments Predictive Value of Tests Prognosis Radionuclide Imaging Radiopharmaceuticals Statistics, Nonparametric Technetium Tc 99m Sestamibi technetium‐99m methoxyisobutylisonitrile |
| title | Evaluation of chemotherapy response using technetium‐99M‐sestamibi scintigraphy in untreated adult malignant lymphomas and comparison with other prognosis factors: A preliminary report |
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