Interleukin-6 Release by Cultured Peripheral Blood Mononuclear Cells Inversely Correlates with Height Velocity, Bone Age, Insulin-like Growth Factor-I, and Insulin-like Growth Factor Binding Protein-3 Serum Levels in Children with Perinatal HIV-1 Infection

• Published in: Clinical immunology (Orlando, Fla.) Fla.), 2000-03, Vol.94 (3), p.212-218
• Main Authors: de Martino, Maurizio, Galli, Luisa, Chiarelli, Francesco, Verrotti, Alberto, Rossi, Maria Elisabetta, Bindi, Giuseppe, Galluzzi, Fiorella, Salti, Roberto, Vierucci, Alberto
• Format: Article
• Language: English
• Subjects: Age Determination by Skeleton; AIDS/HIV; Biological and medical sciences; Body Height; CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes; Cells, Cultured; Child, Preschool; children; Cross-Sectional Studies; Growth Disorders - blood; HIV Seropositivity - congenital; HIV-1; Human viral diseases; Humans; IGF-I; IGFBP-3; IL-6; Infectious diseases; Insulin-Like Growth Factor Binding Protein 3 - blood; Insulin-Like Growth Factor I - analysis; Interleukin-6 - blood; Interleukin-6 - metabolism; Leukocytes, Mononuclear - cytology; Leukocytes, Mononuclear - metabolism; linear growth; Liver Diseases - complications; Medical sciences; Nutritional Status; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids; Viral Load
• ISSN: 1521-6616; 1521-7035
• DOI: 10.1006/clim.2000.4838

Spontaneous and phytohemagglutinin (PHA)-stimulated interleukin (IL)-6 release by cultured peripheral blood mononuclear cells was related to height velocity, bone age, insulin-like growth factor-I (IGF-I), and IGF binding protein-3 (IGFBP-3) serum level standard deviation scores (SDS) of 32 children [aged 91 (median; range 13–151) months] with human immunodeficiency virus-type 1 (HIV-1) perinatal infection and severe disease. Spontaneous and PHA-stimulated IL-6 release inversely correlated with height velocity, bone age, IGF-I, and IGFBP-3 SDS. Ten children with height velocity SDS ≤ −2, compared to 22 children with height velocity SDS > −2, showed higher spontaneous and PHA-stimulated IL-6 release and lower IGF-I and IGFBP-3 SDS (irrespective of CD4-positive T-lymphocyte counts, viral load, liver disease, or nutrition status). IL-6 overproduction may be a mechanism of IGF-I and IGFBP-3 down-regulation and impaired linear growth in children with perinatal HIV-1 infection. Growth-promoting strategies, including targeted anticytokine treatments, could be devised for such children.