Generalized pruritic eruption with suprabasal acantholysis preceeding the development of bullous pemphigoid

We report a patient who presented with a papular pruritic eruption of a 3‐month duration that histologically showed suprabasal acantholysis accompanied of an eosinophilic inflammatory infiltrate that was consistent with the diagnosis of Grover's disease. Later, erythematous plaques and vesicles...

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Bibliographic Details
Published in:Journal of cutaneous pathology 2000-02, Vol.27 (2), p.96-98
Main Authors: Barnadas, María A., Pujol, Ramón M., Curell, Román, Matías‐Guiu, Xavier, Alomar, Agustín
Format: Article
Language:English
Subjects:
Acantholysis - immunology
Acantholysis - pathology
Aged
Aged, 80 and over
Biological and medical sciences
Biopsy
Bullous diseases of the skin
Dermatology
Epidermis - immunology
Epidermis - pathology
Humans
Immunoglobulin G - analysis
Male
Medical sciences
Pemphigoid, Bullous - immunology
Pemphigoid, Bullous - pathology
Pruritus - immunology
Pruritus - pathology
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Summary:We report a patient who presented with a papular pruritic eruption of a 3‐month duration that histologically showed suprabasal acantholysis accompanied of an eosinophilic inflammatory infiltrate that was consistent with the diagnosis of Grover's disease. Later, erythematous plaques and vesicles appeared which showed a histopathological pattern of eosinophilic spongiosis. The direct immunofluorescence (DIF) study showed lineal IgG and C′3 at the dermal epidermal junction which was consistent with the diagnosis of bullous pemphigoid. No anti‐intercellular deposits of immunoglobulin G (IgG) or C′3 were observed. We consider that suprabasal acantholysis may represent the early phase of bullous pemphigoid.
ISSN:0303-6987
1600-0560
DOI:10.1034/j.1600-0560.2000.027002096.x