Hippocampal and amygdaloid damage in partial epilepsy: A cross-sectional MRI study of 241 patients

Patients with drug-refractory temporal lobe epilepsy (TLE) often have hippocampal and amygdaloid damage. The present study investigated the factors associated with the occurrence and severity of damage in patients with partial epilepsy. Magnetic resonance imaging was used to measure the volumes of t...

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Bibliographic Details
Published in:Epilepsy research 2001-07, Vol.46 (1), p.69-82
Main Authors: Salmenperä, Tuuli, Kälviäinen, Reetta, Partanen, Kaarina, Pitkänen, Asla
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age of Onset
Aged
Amygdala
Amygdala - anatomy & histology
Amygdala - pathology
Biological and medical sciences
Epilepsies, Partial - pathology
Epilepsies, Partial - physiopathology
Epilepsy, Temporal Lobe - pathology
Epilepsy, Temporal Lobe - physiopathology
Female
Functional Laterality
Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy
Hippocampus
Hippocampus - anatomy & histology
Hippocampus - pathology
Humans
Magnetic Resonance Imaging
Male
Medical History Taking
Medical sciences
Middle Aged
MRI volumetry
Nervous system (semeiology, syndromes)
Neurology
Reference Values
Regression Analysis
Risk Factors
Seizure number
Seizures, Febrile - physiopathology
Status Epilepticus - pathology
Status Epilepticus - physiopathology
Temporal lobe epilepsy
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Summary:Patients with drug-refractory temporal lobe epilepsy (TLE) often have hippocampal and amygdaloid damage. The present study investigated the factors associated with the occurrence and severity of damage in patients with partial epilepsy. Magnetic resonance imaging was used to measure the volumes of the hippocampus and the amygdala in 241 patients with different durations of epilepsy. We also investigated the association of damage with the location of seizure focus and clinical factors (age at onset of seizures, lifetime seizure number and medical history of complex febrile convulsions, intracranial infection or status epilepticus) with regression analysis. We found that high lifetime seizure number ( P
ISSN:0920-1211
1872-6844
DOI:10.1016/S0920-1211(01)00258-3