Effects of metoprolol and ramipril on action potentials after myocardial infarction in rats

The effects of chronic treatment with the β-adrenoceptor antagonist metoprolol, the angiotensin converting enzyme inhibitor ramipril, their combination, or placebo on action potential configuration 6 weeks after myocardial infarction in rats were studied. Action potentials were measured in isolated...

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Bibliographic Details
Published in:European journal of pharmacology 2000-02, Vol.388 (3), p.263-266
Main Authors: Wagner, Kay-Dietrich, Kamkin, Andre, Kiseleva, Irina, Theres, Heinz, Scholz, Holger, Günther, Joachim
Format: Article
Language:English
Subjects:
Action potential
Action Potentials
Adrenergic beta-Antagonists - pharmacology
Angiotensin-Converting Enzyme Inhibitors - pharmacology
Animals
Biological and medical sciences
Cardiovascular system
Electric Stimulation
Heart - physiopathology
Male
Medical sciences
Metoprolol
Metoprolol - pharmacology
Miscellaneous
Myocardial infarction
Myocardial Infarction - physiopathology
Papillary muscle
Pharmacology. Drug treatments
Ramipril
Ramipril - pharmacology
Rats
Rats, Wistar
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Summary:The effects of chronic treatment with the β-adrenoceptor antagonist metoprolol, the angiotensin converting enzyme inhibitor ramipril, their combination, or placebo on action potential configuration 6 weeks after myocardial infarction in rats were studied. Action potentials were measured in isolated left ventricular posterior papillary muscles and compared with action potentials from a sham operated group without infarction. After infarction, the action potential amplitude was reduced and this phenomenon was partially reversed by metoprolol- and ramipril-treatment. Prolonged repolarisation after infarction compared to sham operated animals was additionally delayed after metoprolol treatment. Thus, metoprolol extends the refractory period, which may counteract tachyarrhythmia.
ISSN:0014-2999
1879-0712
DOI:10.1016/S0014-2999(99)00787-6