Autologous chondrocyte implantation in a canine model: change in composition of reparative tissue with time

The objective of the study was to evaluate the tissue types filling 4-mm diameter defects in the canine trochlear groove 1.5, 3, and 6 months after autologous chondrocyte implantation (ACI). Untreated defects served as controls. Periosteum alone controls were also included at the 1.5-month time peri...

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Bibliographic Details
Published in:Journal of orthopaedic research 2001-05, Vol.19 (3), p.482-492
Main Authors: Breinan, H.A, Minas, T, Hsu, H-P, Nehrer, S, Shortkroff, S, Spector, M
Format: Article
Language:English
Subjects:
Animals
Cartilage, Articular - metabolism
Cartilage, Articular - pathology
Chondrocytes - transplantation
Collagen - metabolism
Dogs
Extracellular Matrix - metabolism
Extracellular Matrix - pathology
Hyalin - metabolism
Models, Animal
Observer Variation
Periosteum - pathology
Periosteum - surgery
Stifle - pathology
Stifle - surgery
Time Factors
Transplantation, Autologous
Wound Healing - physiology
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Summary:The objective of the study was to evaluate the tissue types filling 4-mm diameter defects in the canine trochlear groove 1.5, 3, and 6 months after autologous chondrocyte implantation (ACI). Untreated defects served as controls. Periosteum alone controls were also included at the 1.5-month time period. The results were compared with previously published findings obtained 12 and 18 months postoperative. After 3 months the ACI-treated defects contained significantly more reparative tissue than found in the untreated control group, including twice the amount of hyaline cartilage (HC). These findings, however, were the only significant effects of the ACI treatment when compared to the periosteum alone or empty control groups. The benefits of ACI found at 3 months did not persist to longer time periods. An evaluation of the inter-observer error associated with the histomorphometric method indicated that it was generally less than the inter-animal variation in the results.
ISSN:0736-0266
1554-527X
DOI:10.1016/S0736-0266(00)90015-9