Helical membrane proteins: diversity of functions in the context of simple architecture

During the past year, research on helical membrane proteins has brought insights into the use of deviations from canonical α-helical conformation to support function and the further investigation of the sequestration of protein regions from the lipid bilayer to enhance these structural alternatives....

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Bibliographic Details
Published in:Current Opinion in Structural Biology 2001-06, Vol.11 (3), p.370-376
Main Authors: Ubarretxena-Belandia, Iban, Engelman, Donald M
Format: Article
Language:English
Subjects:
folding
helix interactions
hydrogen bond
Membrane
Membrane Lipids - chemistry
Membrane Lipids - metabolism
Membrane Proteins - chemistry
Membrane Proteins - metabolism
oligomerization
protein
Protein Conformation
Protein Folding
structure/function
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Summary:During the past year, research on helical membrane proteins has brought insights into the use of deviations from canonical α-helical conformation to support function and the further investigation of the sequestration of protein regions from the lipid bilayer to enhance these structural alternatives. Also, the structural roles of polar sidechains, the identification of motifs in helix interactions and the significance of certain topologies on a genome-wide scale have been further explored.
ISSN:0959-440X
1879-033X
DOI:10.1016/S0959-440X(00)00217-7