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Leptin during and after preeclamptic or normal pregnancy: Its relation to serum insulin and insulin sensitivity

Hyperleptinemia may be part of the insulin resistance syndrome. We studied serum leptin in preeclampsia, which is an insulin-resistant state, and sought associations between leptin and insulin or insulin sensitivity during and after pregnancy. Twenty-two proteinuric preeclamptic women and 16 normote...

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Bibliographic Details
Published in:Metabolism, clinical and experimental clinical and experimental, 2000-02, Vol.49 (2), p.259-263
Main Authors: Laivuori, Hannele, Kaaja, Risto, Koistinen, Heikki, Karonen, Sirkka-Liisa, Andersson, Sture, Koivisto, Veikko, Ylikorkala, Olavi
Format: Article
Language:English
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Summary:Hyperleptinemia may be part of the insulin resistance syndrome. We studied serum leptin in preeclampsia, which is an insulin-resistant state, and sought associations between leptin and insulin or insulin sensitivity during and after pregnancy. Twenty-two proteinuric preeclamptic women and 16 normotensive controls were studied during the third trimester. Leptin was higher in preeclampsia (mean ± SE, 34.6 ± 3.9 v 20.0 ± 3.3 μg/L, P = .002) and correlated directly with the level of proteinuria ( r = .47, P = .03) and normal pregnancy ( r = .52, P = .04), where insulin sensitivity as assessed by an intravenous glucose tolerance test showed no relationship to leptin. Leptin was 19.0 ± 3.6 μg/L in 14 preeclamptic women and 10.1 ± 2.0 μg/L ( P = .11) in 11 controls 3 months after delivery. Leptin correlated directly with insulin both in preeclamptic puerperal women ( r = .63, P = .02) and in controls ( r = .81, P = .003). Leptin and insulin sensitivity correlated only in preeclamptic puerperal women ( r = −.59, P = .02). In conclusion, (1) serum leptin is elevated in preeclampsia, (2) insulin is an important determinant of serum leptin in preeclamptic and normotensive women both during pregnancy and in the puerperium, and (3) hyperleptinemia may be part of the insulin resistance syndrome also in women with prior preeclampsia.
ISSN:0026-0495
1532-8600
DOI:10.1016/S0026-0495(00)91559-2