Heritability Heightens Brain Metabolite Differences in Schizophrenia

Single-voxel proton magnetic resonance spectroscopy was performed in 64 medicated schizophrenic patients and 51 healthy subjects. Spectra were obtained from a voxel in the left medial temporal lobe by using a 2.0-tesla whole-body magnetic resonance imaging system. Schizophrenic patients showed a low...

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Bibliographic Details
Published in:The journal of neuropsychiatry and clinical neurosciences 2000, Vol.12 (1), p.95-97
Main Author: Fukuzako, Hiroshi
Format: Article
Language:English
Subjects:
Adult
Aspartic Acid - analogs & derivatives
Aspartic Acid - metabolism
Choline - metabolism
Creatine - metabolism
Dominance, Cerebral - physiology
Energy Metabolism - physiology
Female
Genetic Predisposition to Disease - genetics
Humans
Magnetic Resonance Spectroscopy
Male
Phosphocreatine - metabolism
Reference Values
Schizophrenia - diagnosis
Schizophrenia - genetics
Schizophrenia - physiopathology
Temporal Lobe - physiopathology
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Summary:Single-voxel proton magnetic resonance spectroscopy was performed in 64 medicated schizophrenic patients and 51 healthy subjects. Spectra were obtained from a voxel in the left medial temporal lobe by using a 2.0-tesla whole-body magnetic resonance imaging system. Schizophrenic patients showed a lower N-acetylaspartate creatine-phosphocreatine ratio than did healthy subjects, and this reduction was greater in 13 patients with a family history of psychotic disorders.
ISSN:0895-0172
1545-7222
DOI:10.1176/jnp.12.1.95