Immunological tolerance in an HLA non-identical chimeric twin

Blood group chimeric twins offer a unique opportunity to study immunological tolerance in humans. Although this condition is not as rare as previously considered, detailed immunological studies of blood group chimeras are lacking. We describe here a case of secondary chimerism in a dizygotic twin of...

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Bibliographic Details
Published in:Human immunology 2000-03, Vol.61 (3), p.190-192
Main Authors: Viëtor, Henk E, Hamel, Ben C.J, van Bree, Simone P.M.J, van der Meer, Ellen M.W, Smeets, Dominique F.C.M, Otten, Barto J, Holl, Robert A, Claas, Frans H.J
Format: Article
Language:English
Subjects:
alloreactivity
Chimera - immunology
chimerism
Female
histocompatibility antigen HLA
Histocompatibility Testing
HLA Antigens - immunology
Humans
Immune Tolerance
Male
MLC
Pregnancy
twins
Twins, Dizygotic
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Summary:Blood group chimeric twins offer a unique opportunity to study immunological tolerance in humans. Although this condition is not as rare as previously considered, detailed immunological studies of blood group chimeras are lacking. We describe here a case of secondary chimerism in a dizygotic twin of opposite gender. The karyotypes of the cultured fibroblast confirmed the sex of each twin, all cells in the boy were 46, XY and all cells in the girl were 46, XX. Molecular HLA typing on fibroblasts revealed HLA-DR, DQ and DP disparities between the two siblings. Mixed lymphocyte culture (MLC) revealed a mutual absence of alloreactivity.
ISSN:0198-8859
1879-1166
DOI:10.1016/S0198-8859(99)00183-4