Effects of shivering prevention on haemodynamic and metabolic demands in hypothermic postoperative neurosurgical patients

• Published in: Anaesthesia 2001-06, Vol.56 (6), p.519-519
• Main Authors: Bilotta, F., Pietropaoli, P., La Rosa, I., Spinelli, F., Rosa, G.
• Format: Article
• Language: English
• Subjects: Adult; Aged; Anaesthetic techniques: hypothermia; Analgesics, Non-Narcotic - pharmacology; Anesthesia; Anesthesia depending on type of surgery; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Biological and medical sciences; Blood Pressure - drug effects; Complications: shivering; Craniotomy; Double-Blind Method; Female; Heart Rate - drug effects; Hemodynamics - drug effects; Humans; Hypothermia - physiopathology; Lactic Acid - blood; Male; Medical sciences; Middle Aged; Nefopam - pharmacology; Neurosurgery; Oxygen Consumption - drug effects; Pharmacology: nefopam; Postoperative Complications - physiopathology; Prospective Studies; Recovery; Shivering - drug effects; Shivering - physiology
• ISSN: 0003-2409; 1365-2044
• DOI: 10.1046/j.1365-2044.2001.02057.x

We evaluated the haemodynamic and metabolic effects of prevention of shivering after prophylactic nefopam administration in neurosurgical patients undergoing craniotomy and mild systemic hypothermia (33–35 °C). Forty patients were enrolled in a randomised, double‐blind study. Before extubation, patients received intravenously either nefopam 0.12 mg.kg−1 or an equal volume of saline 0.9%. Left ventricular systolic work index, oxygen consumption index and systemic lactate concentration were recorded before, immediately after and every 20 min for 2 h after extubation. Shivering appeared in two patients treated with nefopam and in all control patients (p