Auditory agnosia and auditory spatial deficits following left hemispheric lesions: evidence for distinct processing pathways

• Published in: Neuropsychologia 2000-01, Vol.38 (6), p.797-807
• Main Authors: Clarke, Stephanie, Bellmann, Anne, Meuli, Reto A, Assal, Gil, Steck, Andreas J
• Format: Article
• Language: English
• Subjects: Adult and adolescent clinical studies; Aged; Agnosia - pathology; Agnosia - physiopathology; Animals; Auditory agnosia; Auditory areas; Auditory localisation; Auditory motion; Auditory Perception - physiology; Biological and medical sciences; Environment; Female; Functional Laterality - physiology; Human; Humans; Macaca; Magnetic Resonance Imaging; Male; Medical sciences; Middle Aged; Neural Pathways - pathology; Organic mental disorders. Neuropsychology; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Severity of Illness Index; Sound Localization - physiology; Space Perception - physiology; Temporal Lobe - diagnostic imaging; Temporal Lobe - pathology; Thalamus - pathology; Tomography, X-Ray Computed
• ISSN: 0028-3932; 1873-3514
• DOI: 10.1016/S0028-3932(99)00141-4

Auditory recognition and auditory spatial functions were studied in four patients with circumscribed left hemispheric lesions. Patient FD was severely deficient in recognition of environmental sounds but normal in auditory localisation and auditory motion perception. The lesion included the left superior, middle and inferior temporal gyri and lateral auditory areas (as identified in previous anatomical studies), but spared Heschl’s gyrus, the acoustic radiation and the thalamus. Patient SD had the same profile as FD, with deficient recognition of environmental sounds but normal auditory localisation and motion perception. The lesion comprised the postero-inferior part of the frontal convexity and the anterior third of the temporal lobe; data from non-human primates indicate that the latter are interconnected with lateral auditory areas. Patient MA was deficient in recognition of environmental sounds, auditory localisation and auditory motion perception, confirming that auditory spatial functions can be disturbed by left unilateral damage; the lesion involved the supratemporal region as well as the temporal, postero-inferior frontal and antero-inferior parietal convexities. Patient CZ was severely deficient in auditory motion perception and partially deficient in auditory localisation, but normal in recognition of environmental sounds; the lesion involved large parts of the parieto-frontal convexity and the supratemporal region. We propose that auditory information is processed in the human auditory cortex along two distinct pathways, one lateral devoted to auditory recognition and one medial and posterior devoted to auditory spatial functions.