Intraoral salivary duct carcinoma: Case report with immunohistochemical observations

Salivary duct carcinoma is an uncommon malignant salivary gland tumor that occurs predominantly in the parotid gland. Oral involvement is extremely rare, with few cases having been reported in the literature. The tumor is characterized by an aggressive behavior and has a poor prognosis. We describe...

Full description

Saved in:
Bibliographic Details
Published in:Oral surgery, oral medicine, oral pathology, oral radiology and endodontics oral medicine, oral pathology, oral radiology and endodontics, 2001-06, Vol.91 (6), p.689-692
Main Authors: Lopes, Márcio Ajudarte, Alves, Fábio de Abreu, Levy, Bernard A., de Almeida, Oslei Paes, Kowalski, Luiz Paulo
Format: Article
Language:English
Subjects:
Biological and medical sciences
Carcinoma - pathology
Carcinoma - secondary
Carcinoma - surgery
Collagen - analysis
Dentistry
Fatal Outcome
Humans
Immunohistochemistry
Keratins - analysis
Ki-67 Antigen - analysis
Laminin - analysis
Liver Neoplasms - secondary
Male
Medical sciences
Middle Aged
Mucin-1 - analysis
Otorhinolaryngology. Stomatology
Palatal Neoplasms - pathology
Palatal Neoplasms - surgery
Prognosis
Proliferating Cell Nuclear Antigen - analysis
Radiotherapy, Adjuvant
Salivary Ducts - pathology
Salivary Ducts - surgery
Salivary Gland Neoplasms - pathology
Salivary Gland Neoplasms - surgery
Salivary Glands, Minor - pathology
Salivary Glands, Minor - surgery
Tumor Suppressor Protein p53 - analysis
Tumors
Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Salivary duct carcinoma is an uncommon malignant salivary gland tumor that occurs predominantly in the parotid gland. Oral involvement is extremely rare, with few cases having been reported in the literature. The tumor is characterized by an aggressive behavior and has a poor prognosis. We describe a case of salivary duct carcinoma arising in the hard palate of a 63-year-old man. Immunohistochemical analysis revealed that tumor cells tested positive for cytokeratin, epithelial membrane antigen, proliferating cell nuclear antigen, Ki67, p53, laminin, and collagen IV. Despite radical surgical resection, bilateral neck dissection, and postoperative radiotherapy, liver metastases developed, and the patient subsequently died of his disease.(Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2001;91:689-92)
ISSN:1079-2104
1528-395X
DOI:10.1067/moe.2001.115028