An image‐based approach for designing and manufacturing craniofacial scaffolds

. Bone tissue engineering (BTE), which combines biomaterial scaffolds with biologically active factors, holds tremendous promise for reconstructing craniofacial defects. A significant challenge in craniofacial reconstructive BTE applications is the complex patient‐specific geometry that must be reco...

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Bibliographic Details
Published in:International journal of oral and maxillofacial surgery 2000-02, Vol.29 (1), p.67-71
Main Authors: Hollister, Scott J., Levy, Richard A., Chu, Tien‐Min, Halloran, John W., Feinberg, Stephen E.
Format: Article
Language:English
Subjects:
Animals
Biocompatible Materials
Biological and medical sciences
biomaterial scaffolds
Biotechnology
Computer-Aided Design
craniofacial reconstruction
Dentistry
Facial Bones - surgery
Head and neck surgery. Maxillofacial surgery. Dental surgery. Orthodontics
Humans
Image Processing, Computer-Assisted
imaging
Magnetic Resonance Imaging
Mandible - surgery
Mandibular Condyle - surgery
Maxillofacial surgery. Dental surgery. Orthodontics
Medical sciences
Orbit - surgery
Prostheses and Implants
Reconstructive Surgical Procedures
Skull - surgery
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Swine
Swine, Miniature
tissue engineering
Tomography, X-Ray Computed
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Summary:. Bone tissue engineering (BTE), which combines biomaterial scaffolds with biologically active factors, holds tremendous promise for reconstructing craniofacial defects. A significant challenge in craniofacial reconstructive BTE applications is the complex patient‐specific geometry that must be reconstructed. In this paper, we present an image‐based approach for designing and manufacturing patient‐specific craniofacial biomaterial scaffolds directly from CT or MRI data. In this approach, voxel density distribution is used to define scaffold topology. The scaffold design topology is created using image processing techniques. This voxel density distribution is then converted to data that can be used to drive a Solid Free‐Form Fabrication machine to either directly build the scaffold or build a mold for the scaffold. Several preliminary applications for craniofacial surgery, including a mandibular condyle scaffold, an orbital floor scaffold, and a general mandibular defect scaffold, are illustrated. Finally, we show applications to in vivo models.
ISSN:0901-5027
1399-0020
DOI:10.1034/j.1399-0020.2000.290115.x