Plasma Angiotensin II, Renin Activity and Serum Angiotensin-Converting Enzyme Activity in Non-Insulin Dependent Diabetes Mellitus Patients with Diabetic Nephropathy

The renin-angiotensin system (RAS) has been unequivocally implicated as a mediator of diabetic complications. The present study was designed to evaluate the RAS in non-insulin dependent diabetic patients with diabetic nephropathy. Plasma renin activity, plasma angiotensin II and serum angiotensin-co...

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Bibliographic Details
Published in:Endocrine Journal 2001, Vol.48(1), pp.25-31
Main Authors: NICOLA, WASSEF, SIDHOM, GLORIA, KHYAT, ZAKAREYA EL, IBRAHIM, SAADIA, SALAH, AMANI, SAYED, ARMED EL
Format: Article
Language:English
Subjects:
Adult
Albuminuria - blood
Angiotensin II
Angiotensin II - blood
Angiotensin-converting enzyme
Blood Pressure
Creatinine - blood
Diabetes Mellitus, Type 2 - blood
Diabetic Nephropathies - blood
Diabetic nephropathy
Female
Humans
Male
Middle Aged
Non-insulin dependent diabetes mellitus
Peptidyl-Dipeptidase A - metabolism
Renin
Renin - blood
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Summary:The renin-angiotensin system (RAS) has been unequivocally implicated as a mediator of diabetic complications. The present study was designed to evaluate the RAS in non-insulin dependent diabetic patients with diabetic nephropathy. Plasma renin activity, plasma angiotensin II and serum angiotensin-converting enzyme (ACE) activity were measured in 45 non-insulin dependent diabetes mellitus (NIDDM) patients and 15 healthy non-diabetic controls. Diabetics were subdivided into 15 normoalbuminuric NIDDM subjects, 15 NIDDM patients with microalbuminuria and 15 diabetics with macroalbuminuria. Mean plasma renin activity for macroalbuminuric diabetics (0.65±0.10ng/ml/hr) was significantly reduced than the controls (1.28±0.37ng/ml/hr) (P
ISSN:0918-8959
1348-4540
DOI:10.1507/endocrj.48.25