Inhibition of human platelet aggregation by amides and ester of salicylic acid with platelet-activating factor analogs

The influence of acetyl salicylic acid (ASA) derivatives with platelet-activating factor (PAF) lipid analogs on PAF-induced human platelet aggregation has been studied. It was found that the ASA amide with an ethanolamine plasmalogen PAF analog (1-0-alk-1'-enyl-2-acetyl-sn-glycero-3-phospho-(N-...

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Bibliographic Details
Published in:Biochemistry (Moscow) 2001-06, Vol.66 (6), p.658-661
Main Authors: Kulikov, V I, Muzya, G I
Format: Article
Language:English
Subjects:
Amides
Amides - chemistry
Anti-Infective Agents - chemistry
Anti-Infective Agents - pharmacology
Esters - chemistry
Humans
Molecular Structure
Platelet Activating Factor - analogs & derivatives
Platelet Activating Factor - pharmacology
Platelet Aggregation - drug effects
Proteins
Salicylic Acid - chemistry
Salicylic Acid - pharmacology
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Summary:The influence of acetyl salicylic acid (ASA) derivatives with platelet-activating factor (PAF) lipid analogs on PAF-induced human platelet aggregation has been studied. It was found that the ASA amide with an ethanolamine plasmalogen PAF analog (1-0-alk-1'-enyl-2-acetyl-sn-glycero-3-phospho-(N-2'-acetoxybenzoyl)ethanolamine) and the ASA ester with a choline plasmalogen PAF analog (1-0-alk-1'-enyl-2-(2'-acetoxybenzoyl)-sn-glycero-3-phosphocholine) at concentrations of 10-7-10-6 M effectively inhibit PAF-induced aggregation of human platelets. In contrast to these compounds, the ASA amide with an alkyl PAF analog (1-0-alkyl-2-acetyl-sn-glycero-3-phospho-(N-2'-acetoxybenzoyl)ethanolamine) did not inhibit PAF-induced platelet aggregation. As possible mechanisms of action of the studied compounds, the blockade of PAF-receptor and cyclooxygenase inhibition are proposed.
ISSN:0006-2979
1608-3040
DOI:10.1023/A:1010211415317