California ground squirrel ( Spermophilus beecheyi) blood sera inhibits crotalid venom proteolytic activity

Some California ground squirrels ( Spermophilus beecheyi) show limited necrosis following envenomation by northern Pacific rattlesnakes ( Crotalus viridis oreganus). This study demonstrates that S. beecheyi blood sera inhibits venom proteases. Sera from rattlesnake-abundant habitats inhibited C. v....

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Bibliographic Details
Published in:Toxicon (Oxford) 2000-05, Vol.38 (5), p.713-721
Main Authors: Biardi, James E, Coss, Richard G, Smith, David G
Format: Article
Language:English
Subjects:
Animal and plant ecology
Animal, plant and microbial ecology
Animals
Antivenins - physiology
Autoecology
Biological and medical sciences
California
Crotalid Venoms - enzymology
Crotalus atrox
Crotalus viridis oreganus
Culture Media
Fundamental and applied biological sciences. Psychology
Gelatinases - antagonists & inhibitors
Gelatinases - metabolism
Mammalia
Sciuridae - blood
Species Specificity
Spermophilus beecheyi
Tissue Inhibitor of Metalloproteinases - physiology
Vertebrata
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Summary:Some California ground squirrels ( Spermophilus beecheyi) show limited necrosis following envenomation by northern Pacific rattlesnakes ( Crotalus viridis oreganus). This study demonstrates that S. beecheyi blood sera inhibits venom proteases. Sera from rattlesnake-abundant habitats inhibited C. v. oreganus venom more effectively than venom from two allopatric rattlesnake species, C. v. viridis and C. atrox, suggesting evolutionary specialization. The pattern of inhibition among squirrel populations corresponds best with history of rattlesnake predation, in contrast to current rattlesnake density.
ISSN:0041-0101
1879-3150
DOI:10.1016/S0041-0101(99)00179-8