Assessing myocardial viability using the coronary flow response to intravenous dobutamine infusion in recent myocardial infarction

Coronary flow response to low-dose (5 and 10 micrograms/kg/min) dobutamine infusion was used to assess myocardial viability at the time of cardiac catheterization in 13 patients (age, 60 +/- 11 years) with recent myocardial infarction. Echocardiographic improvement in regional wall motion performed...

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Bibliographic Details
Published in:Military medicine 2001-06, Vol.166 (6), p.494-499
Main Authors: ROLLEFSON, William A, RUBAL, Bernard J, EBERSOLE, Douglas G, MEGO, David M, BOYD, Sheri Y. N, ZIMRING, Howard J
Format: Article
Language:English
Subjects:
Adenosine
Adult
Aged
Aged, 80 and over
Analysis of Variance
Biological and medical sciences
Blood Flow Velocity
Cardiac catheterization
Cardiotonic Agents
Cardiovascular system
Coronary Circulation
Coronary vessels
Dobutamine
Echocardiography, Doppler
Female
Flow velocity
Heart - diagnostic imaging
Heart attacks
Hibernation
Humans
Intubation
Kinases
Male
Medical imaging
Medical sciences
Middle Aged
Myocardial Contraction
Myocardial Infarction - physiopathology
Pharmacology. Drug treatments
Prognosis
Radionuclide Imaging
Software
Veins & arteries
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Summary:Coronary flow response to low-dose (5 and 10 micrograms/kg/min) dobutamine infusion was used to assess myocardial viability at the time of cardiac catheterization in 13 patients (age, 60 +/- 11 years) with recent myocardial infarction. Echocardiographic improvement in regional wall motion performed 4 to 6 weeks after discharge was used as the marker for viability. Viable patients demonstrated a 2-fold increase in flow from baseline (p < 0.001) during intravenous infusion. In contrast, patients without viability demonstrated no increase in flow. The coronary flow response to dobutamine measured at the time of catheterization shows promise in identifying viable myocardium in postinfarction patients.
ISSN:0026-4075
1930-613X
DOI:10.1093/milmed/166.6.494