The choroid plexuses and the barriers between the blood and the cerebrospinal fluid

1. The fluid homeostasis of the brain depends both on the endothelial blood-brain barrier and on the epithelial blood-cerebrospinal fluid (CSF) barrier located at the choroid plexuses and the outer arachnoid membrane. 2. The brain has two fluid environments: the brain interstitial fluid, which surro...

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Bibliographic Details
Published in:Cellular and molecular neurobiology 2000-04, Vol.20 (2), p.183-196
Main Author: Segal, M B
Format: Article
Language:English
Subjects:
Animals
Blood-Brain Barrier - physiology
Capillary Permeability - physiology
Cerebrospinal Fluid - physiology
Choroid Plexus - blood supply
Choroid Plexus - physiology
Humans
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Summary:1. The fluid homeostasis of the brain depends both on the endothelial blood-brain barrier and on the epithelial blood-cerebrospinal fluid (CSF) barrier located at the choroid plexuses and the outer arachnoid membrane. 2. The brain has two fluid environments: the brain interstitial fluid, which surrounds the neurons and glia, and the CSF, which fills the ventricles and external surfaces of the central nervous system. 3. CSF acts as a fluid cushion for the brain and as a drainage route for the waste products of cerebral metabolism. 4. Recent findings suggest that CSF may also act as a "third circulation" conveying substances secreted into the CSF rapidly to many brain regions.
ISSN:0272-4340
DOI:10.1023/a:1007045605751