Clinical significance of Scedosporium apiospermum in patients with cystic fibrosis

The incidence of airway colonization by Scedosporium apiospermum and of related sensitization was investigated prospectively in 128 patients with cystic fibrosis over a 5-year period, and results were compared with clinical data. Scedosporium apio-spermum, recovered from sputum samples in 11 of 128...

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Bibliographic Details
Published in:European journal of clinical microbiology & infectious diseases 2000-01, Vol.19 (1), p.53-56
Main Authors: CIMON, B, CARRERE, J, VINATIER, J. F, CHAZALETTE, J. P, CHABASSE, D, BOUCHARA, J. P
Format: Article
Language:English
Subjects:
Adolescent
Adult
Antibodies
Antibodies, Fungal - blood
Antigens
Aspergillosis, Allergic Bronchopulmonary - microbiology
Aspergillus fumigatus - immunology
Aspergillus fumigatus - isolation & purification
Biological and medical sciences
Bronchi - microbiology
Child
Child development
Clinical significance
Cystic fibrosis
Cystic Fibrosis - immunology
Cystic Fibrosis - microbiology
Fungal infections
Fungi
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Lung Diseases, Fungal - microbiology
Medical sciences
Mycetoma - microbiology
Other diseases. Semiology
Prospective Studies
Pseudallescheria - immunology
Pseudallescheria - isolation & purification
Pseudallescheria - pathogenicity
Scedosporium apiospermum
Serology
Sputum - microbiology
Yeast
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Summary:The incidence of airway colonization by Scedosporium apiospermum and of related sensitization was investigated prospectively in 128 patients with cystic fibrosis over a 5-year period, and results were compared with clinical data. Scedosporium apio-spermum, recovered from sputum samples in 11 of 128 (8.6%) patients, was the most frequent filamentous fungus after Aspergillus fumigatus. Counterimmuno-electrophoresis, used to detect scedosporiosis serologically, was positive in 27 of 128 (21.1%) patients. The discrepancy between the mycological and serological results may be related to immune cross-reactions between Scedosporium apiospermum and Aspergillus fumigatus. However, symptoms of allergic bronchopulmonary disease were observed in two patients chronically colonized by Scedosporium apiospermum. The results clearly demonstrate that the frequency of this fungus is largely underestimated and that it may trigger an inflammatory response, thus suggesting a pathogenic role in patients with cystic fibrosis.
ISSN:0934-9723
1435-4373
DOI:10.1007/s100960050011