N-acetylcysteine attenuates oxidative burst by neutrophils in response to ergometer rowing with no effect on pulmonary gas exchange

This study evaluated whether the reduction of the neutrophil oxidative burst by N-acetylcysteine improves pulmonary gas exchange during a six minute maximal ergometer row. Healthy trained oarsmen were double-blinded randomized to either N-acetylcysteine (6 g daily for three days) or placebo groups....

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Bibliographic Details
Published in:International journal of sports medicine 2001-05, Vol.22 (4), p.256-260
Main Authors: NIELSEN, H. B, KHARAZMI, A, BOLBJERG, M. L, POULSEN, H. E, PEDERSEN, B. K, SECHER, N. H
Format: Article
Language:English
Subjects:
Acetylcysteine - metabolism
Acetylcysteine - pharmacology
Adult
Biological and medical sciences
Cell metabolism, cell oxidation
Cell physiology
Ergometry
Free Radical Scavengers - metabolism
Free Radical Scavengers - pharmacology
Fundamental and applied biological sciences. Psychology
Humans
Male
Molecular and cellular biology
Neutrophils - drug effects
Neutrophils - physiology
Pulmonary Gas Exchange - drug effects
Pulmonary Gas Exchange - physiology
Respiratory Burst - physiology
Sports - physiology
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Summary:This study evaluated whether the reduction of the neutrophil oxidative burst by N-acetylcysteine improves pulmonary gas exchange during a six minute maximal ergometer row. Healthy trained oarsmen were double-blinded randomized to either N-acetylcysteine (6 g daily for three days) or placebo groups. As determined by the relative changes of the zymosan-stimulated luminol-enhanced chemiluminescence response, N-acetylcysteine suppressed the exercise-induced enhanced neutrophil oxidative burst response to rowing (-7 +/- 6% vs. 17 +/- 8%; P < 0.05). This was the case although the concentration of neutrophils remained similarly elevated above the pre-exercise level in both trials (to 5.4+/-0.5 vs. 5.9+/-0.6 x 10(9) cells x l(-1), respectively, P>0.05). In the placebo and N-acetylcysteine groups, pulmonary ventilation increased and the arterial CO2 partial pressure decreased to the same extent during exercise. Also, at the end of exercise the arterial O2 partial pressure (77 1 vs. 78+/-1 mmHg), haemoglobin O2 saturation (92 +/- 1% vs. 93 +/- 1%) and O2 uptake (5.0 +/- 0.2 vs. 4.9 +/- 0.21 x min(-1)) were not significantly affected by N-acetylcysteine. Equally, two hours after exercise, the pulmonary diffusion capacity was reduced by 7 +/- 2% below the pre-exercise with no significant influence of N-acetylcysteine. We conclude that the neutrophil oxidative burst to exercise does not influence pulmonary gas exchange during and after maximal rowing.
ISSN:0172-4622
1439-3964
DOI:10.1055/s-2001-13817