Cerebrospinal fluid angiotensin-converting enzyme (ACE) correlates with length of illness in schizophrenia

• Published in: Schizophrenia research 2000-01, Vol.41 (2), p.335-340
• Main Authors: Wahlbeck, Kristian, Ahokas, Antti, Nikkilä, Heikki, Miettinen, Kati, Rimón, Ranan
• Format: Article
• Language: English
• Subjects: Acute Disease; Adolescent; Adult; Adult and adolescent clinical studies; Angiotensin I-converting enzyme; Antipsychotic Agents - administration & dosage; Biological and medical sciences; Central renin–angiotensin system; Cerebrospinal fluid; Chronic Disease; Dose-Response Relationship, Drug; Duration of illness; Female; Humans; Length of Stay - statistics & numerical data; Male; Medical sciences; Middle Aged; Peptidyl-Dipeptidase A - cerebrospinal fluid; Psychiatric Status Rating Scales; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Psychoses; Schizophrenia; Schizophrenia - diagnosis; Schizophrenia - drug therapy; Schizophrenia - enzymology
• ISSN: 0920-9964; 1573-2509
• DOI: 10.1016/S0920-9964(99)00059-6

The aim of the study was to evaluate a possible progression with time of cerebrospinal fluid (CSF) angiotensin-converting enzyme (ACE) levels in treated schizophrenia patients. CSF ACE was determined in duplicate by a sensitive inhibitor-binding assay (IBA) from morning CSF samples of 56 acute and chronic in-patients with schizophrenic psychoses diagnosed according to DSM-IV. CSF ACE correlated significantly with length of schizophrenic psychosis ( r=0.39, p=0.003). There was also a positive significant correlation between CSF ACE and duration of current psychotic episode ( r=0.39, p=0.003) as well as duration of current hospitalization ( r=0.66, p