Inhibitory effect of oxcarbazepine on high-frequency firing in peripheral nerve fibers

We assessed the effects of oxcarbazepine, an antiepileptic derivative of carbamazepine, on discharges in single cutaneous afferent fibers produced by repetitive high-frequency stimulation (mimicking the abnormal excitation of peripheral nerves in neuropathic pain and paresthesia). After intravenous...

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Bibliographic Details
Published in:European journal of pharmacology 2001-05, Vol.420 (2), p.119-122
Main Authors: Ichikawa, Kiyoshi, Koyama, Natsu, Kiguchi, Sumiyoshi, Kojima, Masami, Yokota, Toshikatsu
Format: Article
Language:English
Subjects:
Animal
Animals
Anticonvulsants - pharmacology
Anticonvulsants. Antiepileptics. Antiparkinson agents
Biological and medical sciences
Carbamazepine - analogs & derivatives
Carbamazepine - pharmacology
Cats
Data Interpretation, Statistical
Dose-Response Relationship, Drug
Excitation
Medical sciences
Nerve Fibers - drug effects
Nerve Fibers - physiology
Neuropharmacology
Oxcarbazepine
Peripheral nerve
Peripheral Nerves - drug effects
Peripheral Nerves - physiology
Pharmacology. Drug treatments
Repetitive
Time Factors
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Summary:We assessed the effects of oxcarbazepine, an antiepileptic derivative of carbamazepine, on discharges in single cutaneous afferent fibers produced by repetitive high-frequency stimulation (mimicking the abnormal excitation of peripheral nerves in neuropathic pain and paresthesia). After intravenous administration of oxcarbazepine, the later responses in the train dropped out without the earlier ones being affected and, thus, the total number of spikes decreased. The latency of the responses to an individual pulse was unchanged. These results, which indicate that oxcarbazepine inhibits the generation of high-frequency firing without affecting impulse conduction, suggest that this drug may be useful against neuropathic pain and paresthesia.
ISSN:0014-2999
1879-0712
DOI:10.1016/S0014-2999(01)01007-X