Cognitive and vestibulo-proprioceptive components of spatial ability in Parkinson’s disease

Visual–spatial deficits are often associated with Parkinson’s Disease (PD). Recent theories suggest that frontal-basal ganglionic dysfunction affects cognition in PD. Although this hypothesis does not entirely explain spatial deficits in PD, the inappropriate utilization of cues associated with exec...

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Bibliographic Details
Published in:Neuropsychologia 2000-01, Vol.38 (6), p.757-767
Main Authors: Crucian, G.P., Barrett, A.M., Schwartz, R.L., Bowers, D., Triggs, W.J., Friedman, W., Heilman, K.M.
Format: Article
Language:English
Subjects:
Basal Ganglia - physiopathology
Biological and medical sciences
Cognition Disorders - diagnosis
Cognition Disorders - etiology
Cues
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Female
Frontal Lobe - physiopathology
Geriatrics
Humans
Male
Medical sciences
Middle Aged
Neurology
Neuropsychological Tests
Parietal Lobe - physiopathology
Parkinson Disease - complications
Parkinson Disease - physiopathology
Parkinson’s
Proprioception - physiology
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Space Perception - physiology
Spatial cognition
Spatial disorder
Vestibular system
Vestibule, Labyrinth - physiopathology
Visual–spatial disorder
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Summary:Visual–spatial deficits are often associated with Parkinson’s Disease (PD). Recent theories suggest that frontal-basal ganglionic dysfunction affects cognition in PD. Although this hypothesis does not entirely explain spatial deficits in PD, the inappropriate utilization of cues associated with executive dysfunction may induce spatial deficits. Alternatively, the vestibular system is also involved in spatial cognition, and vestibular dysfunction may affect visual–spatial ability in PD. To test these hypotheses, we administered the Water Jar Test, while perturbing vestibulo-proprioceptive input. Non-demented PD patients were significantly less accurate than controls in judging horizontal, and appeared to inappropriately utilize cues. No group effect was found for head tilt. These findings suggest the visual–spatial difficulties seen in PD are related to executive dysfunction that is associated with a disruption of the frontal-basal ganglionic and frontal-parietal systems.
ISSN:0028-3932
1873-3514
DOI:10.1016/S0028-3932(99)00143-8