CpG DNA overcomes hyporesponsiveness to hepatitis B vaccine in orangutans

Oligonucleotides containing immunostimulatory CpG motifs (CpG ODN) have been shown to be potent Th1-type adjuvants for augmenting antigen-specific responses in mice against hepatitis B surface antigen (HBsAg). The hepatitis B virus (HBV) infects only humans and great apes and appears to exist among...

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Bibliographic Details
Published in:Vaccine 2000-03, Vol.18 (18), p.1920-1924
Main Authors: Davis, Heather L., Suparto, Irma, Weeratna, Risini, Jumintarto, Iskandriati, Diah, Chamzah, Siti, Ma’ruf, Amir, Nente, Citrakasih, Pawitri, Dyah, Krieg, Arthur M., Heriyanto, Smits, Willie, Sajuthi, Dondin
Format: Article
Language:English
Subjects:
Adjuvant
Adjuvants, Immunologic - therapeutic use
Animals
Ape Diseases - immunology
Ape Diseases - prevention & control
Biological and medical sciences
CpG Islands - immunology
DNA - immunology
DNA - therapeutic use
DNA vaccines
Fundamental and applied biological sciences. Psychology
Hepatitis Antibodies - biosynthesis
Hepatitis B - immunology
Hepatitis B - prevention & control
Hepatitis B - veterinary
Hepatitis B Surface Antigens - immunology
Hepatitis B vaccine
Hepatitis B Vaccines - immunology
hepatitis B virus
Immune Tolerance - drug effects
Infectious immunity — virus
Microbiology
Non-human primate
Oligodeoxyribonucleotides - immunology
Oligodeoxyribonucleotides - therapeutic use
oligonucleotides
orangutans
Pongo pygmaeus
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies
Virology
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Summary:Oligonucleotides containing immunostimulatory CpG motifs (CpG ODN) have been shown to be potent Th1-type adjuvants for augmenting antigen-specific responses in mice against hepatitis B surface antigen (HBsAg). The hepatitis B virus (HBV) infects only humans and great apes and appears to exist among wild chimpanzees and orangutans. An outbreak of HBV among orangutans being rehabilitated for re-introduction to the jungle caused the death of several animals. A prophylactic vaccination program revealed that orangutans are quite hypo-responsive to a current commercial vaccine compared to results obtained previously in humans and chimpanzees. Addition of CpG ODN to hepatitis B vaccine greatly increased the seroconversion rate and the titers of antibody against HBsAg (anti-HBs). This is the first demonstration of CpG DNA in a great ape and the results have important implications for the vaccination of humans against HBV and other diseases.
ISSN:0264-410X
1873-2518
DOI:10.1016/S0264-410X(99)00443-0