Further evidence for the existence of a volume-activated taurine efflux pathway in rat mammary tissue independent from volume-sensitive Cl- channels

The effect of cell‐swelling, induced by a hyposmotic shock, on the fractional loss of taurine, D‐aspartate and iodide from lactating rat mammary tissue explants has been examined. In paired experiments, cell‐swelling markedly increased the fractional efflux of taurine but not that of D‐aspartate. Si...

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Bibliographic Details
Published in:Acta physiologica Scandinavica 2000-02, Vol.168 (2), p.295-299
Main Authors: SHENNAN, D. B, THOMSON, J
Format: Article
Language:English
Subjects:
Animals
Aspartic Acid - metabolism
Biological and medical sciences
Biological Transport, Active
Cell Size
Chloride Channels - metabolism
Female
Fundamental and applied biological sciences. Psychology
In Vitro Techniques
Iodides - metabolism
Kinetics
Lactation - metabolism
mammary
Mammary Glands, Animal - cytology
Mammary Glands, Animal - metabolism
Mother. Fetoplacental unit. Mammary gland. Milk
Osmotic Pressure
Pregnancy. Parturition. Lactation
Rats
Rats, Wistar
taurine
Taurine - metabolism
Vertebrates: reproduction
volume-activated transport
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Summary:The effect of cell‐swelling, induced by a hyposmotic shock, on the fractional loss of taurine, D‐aspartate and iodide from lactating rat mammary tissue explants has been examined. In paired experiments, cell‐swelling markedly increased the fractional efflux of taurine but not that of D‐aspartate. Similarly, in paired experiments, a hyposmotic challenge stimulated taurine release but not iodide efflux. The results suggest that volume‐activated taurine efflux from mammary tissue explants is via a pathway independent from volume‐sensitive anion channels. It is apparent that the volume‐activated taurine efflux pathway in mammary tissue is not the volume‐sensitive organic osmolyte–anion channel which has been described in other cells. Therefore, the results of this study together with others in the literature constitute prima facie evidence for the existence of more than one type of swelling‐activated pathway which accepts taurine as a substrate.
ISSN:0001-6772
1365-201X
DOI:10.1046/j.1365-201x.2000.00658.x