The effect of previous administration of nizatidine on the neuromuscular effects of vecuronium and the effect of nizatidine on gastric secretion

Nizatidine, a new H2-receptor antagonist, has been reported to inhibit acetylcholinesterase activity. This could lead to an interaction with neuromuscular blocking drugs. This study examined the effects of nizatidine on the actions of vecuronium. Oral nizatidine has been reported to be an effective...

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Bibliographic Details
Published in:Anaesthesia and intensive care 2000-02, Vol.28 (1), p.46-48
Main Authors: WAJIMA, Z, SHITARA, T, INOUE, T, YOSHIKAWA, T, OGAWA, R
Format: Article
Language:English
Subjects:
Anesthetics. Neuromuscular blocking agents
Biological and medical sciences
Digestive system
Elective Surgical Procedures
Female
Gastric Acid - metabolism
Gastric Acidity Determination
Histamine H2 Antagonists - administration & dosage
Histamine H2 Antagonists - pharmacology
Humans
Male
Medical sciences
Middle Aged
Neuromuscular Nondepolarizing Agents
Neuropharmacology
Nizatidine - administration & dosage
Nizatidine - pharmacology
Pharmacology. Drug treatments
Prospective Studies
Vecuronium Bromide
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Summary:Nizatidine, a new H2-receptor antagonist, has been reported to inhibit acetylcholinesterase activity. This could lead to an interaction with neuromuscular blocking drugs. This study examined the effects of nizatidine on the actions of vecuronium. Oral nizatidine has been reported to be an effective protective agent against acid aspiration syndrome, and we reevaluated this effect. The control group (n = 10) received a placebo with water 50 ml and the nizatidine group (n = 10) received nizatidine 300 mg with water 50 ml two hours before arrival in the operating room. Gastric contents were aspirated and the volume and pH measured before induction of anaesthesia. Anaesthesia was induced in all patients with thiopentone 5 mg/kg and 1.5% isoflurane in 98.5% oxygen followed by vecuronium 0.1 mg/kg. Vecuronium onset time and duration time 25 (time from injection until recovery of 25% of vaseline twitch amplitude) were obtained using electromyography. There were no significant differences between the two groups in vecuronium onset time or duration time 25. Gastric fluid volume was greater and gastric pH was lower in the control group than in the nizatidine group. 70% of the control group and none of the nizatidine group (P < 0.005) had a gastric content pH < 2.5 or volume > 25 ml.
ISSN:0310-057X
1448-0271
DOI:10.1177/0310057x0002800108