AIDS and cancer in the era of highly active antiretroviral therapy (HAART)

Combination therapy with protease inhibitors and nucleoside analogues dramatically suppresses plasma HIV-1 RNA and delays progression to AIDS, but the impact on HIV-associated malignancy remains to be established. Observational and time–trend data indicate that the incidence of Kaposi's sarcoma...

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Bibliographic Details
Published in:European journal of cancer (1990) 2001-07, Vol.37 (10), p.1316-1319
Main Author: Rabkin, C.S.
Format: Article
Language:English
Subjects:
AIDS-related malignancy
Antiretroviral Therapy, Highly Active - methods
Biological and medical sciences
Carcinogenesis, carcinogens and anticarcinogens
Epstein–Barr virus
HAART
highly active antiretroviral therapy
Hodgkin Disease - drug therapy
Human herpesvirus-8
Human immunodeficiency virus 1
Human viral diseases
Humans
Infectious diseases
Kaposi's sarcoma
Lymphoma, AIDS-Related - complications
Lymphoma, AIDS-Related - drug therapy
Medical sciences
Non-Hodgkin's lymphoma
Risk Factors
Sarcoma, Kaposi - drug therapy
Tumors
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
Viruses
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Summary:Combination therapy with protease inhibitors and nucleoside analogues dramatically suppresses plasma HIV-1 RNA and delays progression to AIDS, but the impact on HIV-associated malignancy remains to be established. Observational and time–trend data indicate that the incidence of Kaposi's sarcoma (KS) and primary brain lymphoma have decreased, but suggest that current therapies have not had a proportionate effect on systemic non-Hodgkin's lymphomas (NHL). As opportunistic infection and mortality are yielding to advances in antiretroviral therapy, lymphoma may increase in importance as a cause of AIDS-related morbidity and mortality. Further improvements in the long-term consequences of HIV infection will depend on better prevention and treatment of this serious malignant complication.
ISSN:0959-8049
1879-0852
DOI:10.1016/S0959-8049(01)00104-6