Activation of neurospecific gene expression by antennapedia homeobox peptide

Antennapedia homeobox peptide has been reported to enhance neurite outgrowth and branching. Thus it is of interest to investigate whether antennapedia peptide is capable of modulating the expression of genes related to different events of neuronal development. In this paper we report the enhancement...

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Bibliographic Details
Published in:International journal of developmental neuroscience 2000-02, Vol.18 (1), p.93-99
Main Authors: Biagioni, Stefano, Ciuffini, Laura, De Jaco, Antonella, Vignoli, Anna Lidia, Augusti‐Tocco, Gabriella
Format: Article
Language:English
Subjects:
Acetylcholinesterase
Acetylcholinesterase - metabolism
Animals
antennapedia homeobox peptide
Antennapedia Homeodomain Protein
Antennapedia peptide
Blotting, Northern
Blotting, Western
Cells, Cultured
Chick Embryo
Choline acetyltransferase
Choline O-Acetyltransferase - genetics
Development
Gene Expression Regulation, Developmental
Gene Expression Regulation, Enzymologic
Homeodomain Proteins - analysis
Homeodomain Proteins - genetics
Muscle, Skeletal - cytology
Muscle, Skeletal - embryology
Neurites - chemistry
Neurites - enzymology
Neurofilament
Neurofilament Proteins - analysis
Neurofilament Proteins - genetics
Neurons - chemistry
Neurons - enzymology
Neurons - ultrastructure
Nuclear Proteins
RNA, Messenger - analysis
Spinal Cord - cytology
Spinal Cord - embryology
Transcription Factors - analysis
Transcription Factors - genetics
Transcriptional Activation - physiology
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Summary:Antennapedia homeobox peptide has been reported to enhance neurite outgrowth and branching. Thus it is of interest to investigate whether antennapedia peptide is capable of modulating the expression of genes related to different events of neuronal development. In this paper we report the enhancement of a 68 KDa neurofilament subunit, choline acetyltransferase and acetylcholinesterase expression in spinal cord neurons, elicited by antennapedia peptide. Modulation of gene expression is different with respect to each gene product analyzed, suggesting a specific action of the peptide on diverse genes controlling different events of neuronal differentiation.
ISSN:0736-5748
1873-474X
DOI:10.1016/S0736-5748(99)00077-5