Histological diversity of vasculitic lesions in MPO-ANCA-positive autopsy cases

To investigate the variety of histological features of vasculitic lesions in myeloperoxidase‐specific antineutrophil cytoplasmic antibody (pANCA)‐related vasculitis, retrospective pathological analysis was done on 13 autopsy cases, collected from 1990 to 1998 at five hospitals. These cases were clas...

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Bibliographic Details
Published in:Pathology international 2001-06, Vol.51 (6), p.460-466
Main Authors: Sano, Kenji, Sakaguchi, Nobuki, Ito, Makoto, Koyama, Masamichi, Kobayashi, Motohiro, Hotchi, Masao
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Antibodies, Antineutrophil Cytoplasmic - blood
diffuse alveolar hemorrhage
Female
Glomerulonephritis - complications
Glomerulonephritis - metabolism
Glomerulonephritis - pathology
Hemorrhage - complications
Hemorrhage - metabolism
Hemorrhage - pathology
Humans
Kidney Glomerulus - immunology
Kidney Glomerulus - pathology
Lung Diseases - complications
Lung Diseases - metabolism
Lung Diseases - pathology
Male
microscopic polyangitis
microscopic polyarteritis nodosa
Middle Aged
myeloperoxidase-antineutrophil cytoplasmic antigen
necrotizing crescentic glomerulonephritis
Peroxidase - immunology
Polyarteritis Nodosa - immunology
Polyarteritis Nodosa - pathology
Pulmonary Alveoli - immunology
Pulmonary Alveoli - pathology
pulmonary-renal syndrome
Syndrome
Vasculitis - blood
Vasculitis - immunology
Vasculitis - pathology
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Summary:To investigate the variety of histological features of vasculitic lesions in myeloperoxidase‐specific antineutrophil cytoplasmic antibody (pANCA)‐related vasculitis, retrospective pathological analysis was done on 13 autopsy cases, collected from 1990 to 1998 at five hospitals. These cases were classified into three groups: (i) pulmonary–renal syndrome characterized by capillaritis of lung and glomeruli with occasional small‐vessel arteritis and/or phlebitis; (ii) glomerular capillaritis without pulmonary involvement associated with significant small‐vessel arteritis; and (iii) extensive distribution of small‐vessel arteritis with no capillary involvement. The results suggest that pANCA‐related vasculitis encompasses a wide variety of vasculitic syndromes, including pulmonary–renal syndrome, microscopic polyarteritis nodosa, and classic polyarteritis nodosa. pANCA may contribute to pathogenesis in all of these cases.
ISSN:1320-5463
1440-1827
DOI:10.1046/j.1440-1827.2001.01225.x