A New Dehydrogeranylgeraniol Antioxidant from Saururus cernuus that Inhibits Intracellular Reactive Oxygen Species (ROS)-Catalyzed Oxidation within HL-60 Cells

A new triene, 12,13-dehydrogeranylgeraniol (1), was isolated from the aquatic plant Saururus cernuus and its structure determined spectroscopically. Compound 1 inhibits PMA-induced peroxide-catalyzed oxidation of 2',7'-dichlorodihydrofluorescein dye (DCFH) by reactive oxygen species (ROS)...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2001-06, Vol.64 (6), p.693-695
Main Authors: RAJBHANDARI, Ira, TAKAMATSU, Satoshi, NAGLE, Dale G.
Format: Article
Language:English
Subjects:
Antineoplastic Agents, Phytogenic - pharmacology
Antioxidants - pharmacology
Biological and medical sciences
Diterpenes - chemistry
Diterpenes - isolation & purification
Flow Cytometry
Free Radical Scavengers - pharmacology
General pharmacology
HL-60 Cells
Humans
Magnetic Resonance Spectroscopy
Medical sciences
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plants, Medicinal - chemistry
Reactive Oxygen Species - metabolism
Saururus cernuus
Spectrophotometry, Infrared
Spectrophotometry, Ultraviolet
Spectroscopy, Fourier Transform Infrared
United States
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Summary:A new triene, 12,13-dehydrogeranylgeraniol (1), was isolated from the aquatic plant Saururus cernuus and its structure determined spectroscopically. Compound 1 inhibits PMA-induced peroxide-catalyzed oxidation of 2',7'-dichlorodihydrofluorescein dye (DCFH) by reactive oxygen species (ROS) within human promyelocyctic HL-60 cells.
ISSN:0163-3864
1520-6025
DOI:10.1021/np0101346