Head growth in Rett syndrome

The longitudinal development of head growth was investigated in girls with Rett syndrome. Measurements were taken retrospectively from different kinds of records. Growth retardation was expressed in standard deviation (SD) scores. In classic types, the mean head circumference fell successively to 2...

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Bibliographic Details
Published in:Acta Paediatrica 2000-02, Vol.89 (2), p.198-202
Main Authors: Hagberg, G, Stenbom, Y, Engerström, I Witt
Format: Article
Language:English
Subjects:
Age Factors
Biological and medical sciences
Body height
Cephalometry
Child
Child Development
Child, Preschool
Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes
Female
Head - growth & development
head growth
Humans
Infant
Longitudinal Studies
Medical sciences
motor disability
Motor Skills
Nervous system (semeiology, syndromes)
Neurology
Retrospective Studies
Rett syndrome
Rett Syndrome - diagnosis
Rett Syndrome - physiopathology
Severity of Illness Index
Sweden
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Summary:The longitudinal development of head growth was investigated in girls with Rett syndrome. Measurements were taken retrospectively from different kinds of records. Growth retardation was expressed in standard deviation (SD) scores. In classic types, the mean head circumference fell successively to 2 SD scores below the norm at the age of 4 y. After the age of 8 y it stabilized close to –3 SD scores. The degree of deceleration correlated strongly to the age at which a deceleration of 1 SD score had occurred. In forme fruste variants, the mean head circumference was within normal limits; however, it was significantly below the norm (–0.8 SD scores). Body height deviated to –2 SD scores at the age of 6 y and was highly correlated to decline in head growth. When head growth was related to the severity of motor disability, there was a continuum from almost normal head growth with well‐preserved gross motor function and some preserved fine motor function to a marked deceleration in head growth with maximum gross and fine motor disability.
ISSN:0803-5253
1651-2227
DOI:10.1111/j.1651-2227.2000.tb01216.x