Polyamidoamine Starburst® dendrimers as solubility enhancers

The solubility of the hydrophobic drug ibuprofen has been compared in an aqueous solution of polyamidoamine (PAMAM) G4 dendrimer and sodium dodecyl sulphate (SDS). The PAMAM G4 dendrimer solution significantly enhanced the solubility of ibuprofen compared to 2% SDS solution. It was found that the so...

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Bibliographic Details
Published in:International journal of pharmaceutics 2000-03, Vol.197 (1), p.239-241
Main Authors: Milhem, O.M, Myles, C, McKeown, N.B, Attwood, D, D’Emanuele, A
Format: Article
Language:English
Subjects:
Biological and medical sciences
Dendrimers
Excipients
General pharmacology
Hydrogen-Ion Concentration
Ibuprofen
Ibuprofen - analysis
Ibuprofen - chemistry
Medical sciences
PAMAM G4 dendrimer
Pharmacology. Drug treatments
Physicochemical properties. Structure-activity relationships
Polyamines - chemistry
Sodium Dodecyl Sulfate
Solubility
Solubility enhancement
Spectrophotometry, Ultraviolet
Surface-Active Agents
Temperature
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Summary:The solubility of the hydrophobic drug ibuprofen has been compared in an aqueous solution of polyamidoamine (PAMAM) G4 dendrimer and sodium dodecyl sulphate (SDS). The PAMAM G4 dendrimer solution significantly enhanced the solubility of ibuprofen compared to 2% SDS solution. It was found that the solubility of ibuprofen in dendrimer solution was directly proportional to dendrimer concentration and inversely proportional to temperature. The influence of dendrimer solution pH on the solubility enhancement of ibuprofen suggests that it involves an electrostatic interaction between the carboxyl group of the ibuprofen molecule and the amine groups of the dendrimer molecule.
ISSN:0378-5173
1873-3476
DOI:10.1016/S0378-5173(99)00463-9