The MHC influences NK and NKT cell functions associated with immune abnormalities and lifespan

The lifespans of H-2 congenic mice differ significantly. The B10.AKM (H-2 m) strain has a median survival time (MST) of 15 months, whereas the B10.BR (H-2 k) strain has an MST of 24 months. It was previously shown that B10.AKM mice at 13–15 months of age have immunological function comparable to tho...

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Bibliographic Details
Published in:Mechanisms of ageing and development 2000-02, Vol.113 (2), p.117-134
Main Authors: Dubey, Devendra P., Husain, Zaheed, Levitan, Edward, Zurakowski, David, Mirza, Nadeem, Younes, Souhad, Coronell, Carlos, Yunis, David, Yunis, Edmond J.
Format: Article
Language:English
Subjects:
Aging - genetics
Aging - immunology
Aging - metabolism
Animals
Base Sequence
Biological and medical sciences
Calcium Signaling
CD4-Positive T-Lymphocytes - immunology
CD4-Positive T-Lymphocytes - metabolism
Cytokines
Cytotoxicity, Immunologic
DNA Primers - genetics
Female
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Immunobiology
Immunologic Memory
In Vitro Techniques
Interferon-gamma - genetics
Interleukin-4 - genetics
Killer Cells, Natural - immunology
Killer Cells, Natural - metabolism
Lifespan
Longevity - genetics
Longevity - immunology
Longevity - physiology
Lymphocyte Activation
Major Histocompatibility Complex
Male
MHC congenic mice
Mice
Mice, Congenic
Mice, Inbred DBA
Modulation of the immune response (stimulation, suppression)
NKT
RNA, Messenger - genetics
RNA, Messenger - metabolism
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Summary:The lifespans of H-2 congenic mice differ significantly. The B10.AKM (H-2 m) strain has a median survival time (MST) of 15 months, whereas the B10.BR (H-2 k) strain has an MST of 24 months. It was previously shown that B10.AKM mice at 13–15 months of age have immunological function comparable to those of B10.BR mice at 22–26 months of age. These functions include: a low proliferative response, reduced levels of intracellular calcium release [Ca 2+] i, and an increase in the frequency of memory helper T-cells (CD4 +CD44 hiCD45RB lo). In this report similar deficiencies were demonstrated in B10.AKM mice at 2–4 months of age and show that activated spleen NK1.1 +CD4 + T (NKT) cells from young B10.AKM mice produce a significantly higher level of IL-4 but a lower level of IFN-γ as compared to NKT cells from B10.BR mice of the same age. Also, the cytotoxic activity of natural killer (NK) cells from spleens of young (2–4 months) as well as adult (12–16 months) B10.AKM mice is significantly lower ( P
ISSN:0047-6374
1872-6216
DOI:10.1016/S0047-6374(99)00102-5