Therapeutic effects of parenteral β-lactam antibiotics on experimental otitis media caused by penicillin-resistant Streptococcus pneumoniae in guinea-pigs

The therapeutic effects of parenteral beta-lactam antibiotics were evaluated in experimental acute otitis media caused by penicillin-resistant Streptococcus pneumoniae (PRSP) in guinea-pigs. Cefotaxime, ceftriaxone and piperacillin significantly reduced viable cell counts of PRSP in the middle ear a...

Full description

Saved in:
Bibliographic Details
Published in:Journal of antimicrobial chemotherapy 2000-03, Vol.45 (3), p.311-314
Main Authors: HORI, R, ARAKI, H, YONEZAWA, M, MINAMI, S, WATANABE, Y
Format: Article
Language:English
Subjects:
Animals
Anti-Bacterial Agents - administration & dosage
Anti-Bacterial Agents - pharmacokinetics
Anti-Bacterial Agents - therapeutic use
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Area Under Curve
beta-Lactams
Biological and medical sciences
Ear, Middle - metabolism
Guinea Pigs
Half-Life
Infusions, Parenteral
Male
Medical sciences
Microbial Sensitivity Tests
Otitis Media - drug therapy
Otitis Media - microbiology
Pharmacology. Drug treatments
Streptococcal Infections - drug therapy
Streptococcal Infections - microbiology
Streptococcus pneumoniae
Streptococcus pneumoniae - drug effects
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The therapeutic effects of parenteral beta-lactam antibiotics were evaluated in experimental acute otitis media caused by penicillin-resistant Streptococcus pneumoniae (PRSP) in guinea-pigs. Cefotaxime, ceftriaxone and piperacillin significantly reduced viable cell counts of PRSP in the middle ear at a dose of 50 mg/kg bd for 3 days (P < 0.01 compared with control). The therapeutic effects of cefotaxime, ceftriaxone and piperacillin were superior to those of cefotiam and ceftazidime. These therapeutic effects reflected both in vitro activity and pharmacokinetic properties of the drugs.
ISSN:0305-7453
1460-2091
DOI:10.1093/jac/45.3.311